Table 1

Significant (p<0.05) genetic associations observed in genotyped SNPs, with comparison p values from the TASC study

CHR	SNP	Position	Locus	Allele 1	Allele 2	Effect	Standard error	p Value	OR (95% CI)	TASC OR (95% CI)	TASC p value
12	rs4149577	6317783	TNFRSF1A	T	C	−0.23	0.069	8.2×10⁻⁴	0.79 (0.69 to 0.91)	0.9 (0.79 to 1.01)	0.052
17	rs2293152	37735055	STAT3	C	G	−0.21	0.065	0.0015	0.81 (0.72 to 0.92)	0.88 (0.81 to 0.96)	0.0016
5	rs27038	96138710	ERAP1	A	G	0.17	0.065	0.0091	1.18 (1.04 to 1.34)	1.26 (1.17 to 1.35)	2.2×10⁻⁷
5	rs27037	96120450	ERAP1	T	G	0.17	0.066	0.0092	1.19 (1.04 to 1.35)	1.28 (1.17 to 1.39)	1.2×10⁻⁵
17	rs1053005	37719436	STAT3	G	A	0.16	0.069	0.017	1.18 (1.03 to 1.35)	0.95 (0.85 to 1.05)	0.32
5	rs27980	96123651	ERAP1	C	A	−0.15	0.064	0.022	0.86 (0.76 to 0.98)	0.97 (0.89 to 1.06)	0.52
2	rs10865331	62404976	2p15	A	G	0.15	0.065	0.023	1.16 (1.02 to 1.32)	1.35 (1.27 to 1.42)	1.9×10⁻¹⁴
5	rs27619	96143821	ERAP1	C	A	−0.13	0.065	0.038	0.87 (0.77 to 0.99)	0.8 (0.72 to 0.88)	8.9×10⁻⁸
5	rs469783	96147280	ERAP1	T	C	−0.13	0.065	0.039	0.88 (0.77 to 0.99)	0.77 (0.67 to 0.86)	1.1×10⁻⁷
5	rs7711564	96121975	ERAP1	G	C	−0.13	0.065	0.045	0.88 (0.77 to 1)	1 (0.92 to 1.08)	0.96
6	rs7740197	26771457	6p22.1	G	A	−0.20	0.10	0.049	0.82 (0.67 to 1)	1.3 (1.19 to 1.41)	4.1×10⁻⁶

CHR, chromosome; SNP, single nucleotide polymorphism; TASC, Australo-Anglo-American Spondyloarthritis Consortium.