In the left part each cell represents the number of patients with RRP/the total number of patients per cell. In the right part numbers represent the probability of RRP (CI) according to the ASPIRE matrix, except in the lower part where cells represent NNT. Colours correspond to levels of RRP probability according to the ASPIRE matrix: blue 0–10%, green 10–20%, yellow 20–30%, orange 30–40%, red >40%. The bright pink line represents a cut-off of 9.17 for NNT, with a positive predictive value of 12.6% and a negative predictive value of 100% for the prediction of RRP in our population.

ASPIRE, Active-Controlled Study of Patients Receiving Infliximab for Treatment of Rheumatoid Arthritis of Early Onset; ESR, erythrocyte sedimentation rate; IFX, infliximab; MTX, methotrexate; NNT, number needed to treat; RF, rheumatoid factor; RRP, rapid radiographic progression.