Sensitivity and specificity of the prespecified candidate criteria for peripheral SpA, ESSG, Amor and modified criteria in patients with peripheral arthritis, enthesitis and/or dactylitis in 266 patients (n=176 peripheral SpA, n=90 no SpA)
| Sets of criteria for peripheral SpA | Sensitivity (%) | Specificity (%) | Set of criteria voted for by ASAS |
|---|---|---|---|
| Prespecified candidate criteria: | |||
| ASAS candidate criteria set 1: arthritis/enthesitis (any)/dactylitis plus ≥ 2 parameters | 62.5 | 90.0 | |
| ASAS candidate criteria set 1_h: arthritis/enthesitis (heel only)/dactylitis plus ≥ 2 parameters | 54.0 | 91.1 | |
| ASAS candidate criteria set 2: arthritis/enthesitis (any)/dactylitis plus (A) ≥ 1 of psoriasis, IBD, preceding infection or (B) ≥ 2 other parameters | 67.0 | 84.4 | |
| ASAS candidate criteria set 2_h: arthritis/enthesitis (heel only)/dactylitis plus (A) anyone of psoriasis, IBD, preceding infection or (B) ≥ 2 other parameters | 56.8 | 85.6 | |
| Modifications of prespecified candidate criteria | |||
| Set 1A: arthritis/enthesitis (any)/dactylitis plus ≥ 1 parameter | 92.6 | 55.6 | |
| Set 1A_h: arthritis/enthesitis (heel only)/dactylitis plus ≥ 1 parameter | 84.7 | 61.1 | |
| Set 2B: arthritis/enthesitis (any)/dactylitis plus (A) ≥ 1 of psoriasis, IBD, preceding infection, HLA-B27, or (B) ≥ 2 other parameters | 74.4 | 82.2 | |
| Set 2B_h: arthritis/enthesitis (heel only)/dactylitis plus (A) ≥ 1 of psoriasis, IBD, preceding infection, HLA-B27, or (B) ≥ 2 other parameters | 67.6 | 83.3 | |
| Set 2C: arthritis/enthesitis (any)/dactylitis plus (A) ≥ 1 of psoriasis, IBD, preceding infection, HLA-B27, uveitis, or (B) ≥ 2 other parameters | 75.0 | 82.2 | |
| Set 2C_h: arthritis/enthesitis (heel only)/dactylitis plus (A) ≥ 1 of psoriasis, IBD, preceding infection, HLA-B27, uveitis, or (B) ≥ 2 other parameters | 68.2 | 83.3 | |
| Set 2D: arthritis/enthesitis (any)/dactylitis plus (A) ≥ 1 of psoriasis, IBD, preceding infection, HLA-B27, uveitis, sacroiliitis on imaging, or (B) ≥ 2 other parameters* | 77.8 | 82.2 | + |
| ESSG/Amor criteria: | |||
| ESSG | 55.1 | 81.1 | |
| Modified ESSG (with MRI)† | 62.5 | 81.1 | |
| Amor | 35.2 | 97.8 | |
| Modified Amor (with MRI)‡ | 39.8 | 97.8 | |
↵* Sacroiliitis on imaging refers to definite radiographic sacroiliitis according to the mod. New York criteria or sacroiliitis on MRI according to the consensus definition.9
↵† The ESSG criteria were modified in that active sacroiliitis on MRI was added to the list of parameters of which at least one is required in addition to inflammatory back pain or synovitis.
↵‡ The Amor criteria were modified in that active sacroiliitis on MRI was assigned three scoring points, similar to definite radiographic sacroiliitis. Thus, presence of either definite radiographic sacroiliitis or active sacroiliitis on MRI yielded three points (maximum of three points for the imaging criterion).
ASAS, Assessment of SpondyloArthritis international Society; ESSG, European Spondylarthropathy Study Group; HLA-B27, human leucocyte antigen B27; IBD, inflammatory bowel disease; SpA, spondyloarthritis.