Baseline values and change scores in clinical and imaging parameters
| Baseline | Δ6 months | Δ12 months | |
|---|---|---|---|
| Clinical | |||
| DAS28(3)-CRP | 4.8 (1.0) | −1.7 (1.0) | −2.1 (1.0) |
| n=52 (baseline), n=42 (6), n=36 (12) | 4.7 (2.8 to 7.1) | −1.8 (−3.9 to 0.5)* | −2.2 (−4.0 to −0.1)† |
| Tender joint count (28) n=52 | 8.8 (6.4) | −6.0 (5.8) | −6.9 (5.9) |
| (baseline), n=42 (6), n=36 (12) | 9 (0 to 26) | −4.5 (−20 to 5)* | −4.5 (−17 to 4)* |
| Swollen joint count (28) | 8.3 (4.3) | −6.3 (4.3) | −7.6 (4.8) |
| n=52 (baseline), n=42 (6), n=36 (12) | 8 (1 to 20) | −6.0 (−14 to 4)* | −7.5 (−15 to 7)† |
| CRP (mg/l) n=52 (baseline), | 29 (31.8) | −19 (27.8) | −22 (28.8) |
| n=42 (6), n=36 (12) | 21 (0 to 136) | −11 (−105 to 16)* | −11 (−107 to 4)* |
| HAQ | 1.2 (0.6) | −0.52 (0.5) | −0.62 (0.5) |
| n=52 (baseline), n=42 (6), n=36 (12) | 1.125 (0 to 2.125) | −0.5 (−2.125 to 0.5)* | −0.625 (−2.125 to 0.375)* |
| Imaging of inflammation | |||
| MRI synovitis score (0–21) | 14.7 (3.7) | −1.2 (3.0) | −1.7 (3.6) |
| n=50 (baseline), n=37 (6), n=31 (12) | 15 (3 to 21) | −1 (−8 to 7)* | −1 (−7 to 11)* |
| MRI bone oedema score (0–69) | 9.8 (10.3) | −1.3 (6.2) | −1.8 (7.0) |
| n=51 (baseline), n=37 (6), n=32 (12) | 7 (0 to 42) | 0 (−19 to 17) | −1 (−22 to 17) |
| Ultrasonography synovitis score (0–42) | 19.9 (9.3) | −4.8 (6.2) | −7.6 (7.2) |
| n=47 (baseline), n=39 (6), n=33 (12) | 19 (4 to 41) | −5 (−20 to 5)* | −6 (−26 to 5)* |
| Ultrasonography power Doppler score (0–42) | 11.7 (5.7) | −4.1 (5.1) | −5.9 (6.7) |
| n=47 (baseline), n=39 (6), n=33 (12) | 11 (3 to 26) | −4 (−16 to 9)* | −5 (−22 to 6)* |
| Imaging of destruction | |||
| MRI erosion score (0–230) | 22 (27.1) | 0.3 (1.7) | 0.4 (2.9) |
| n=50 (baseline), n=39 (6), n=33 (12) | 16 (3 to 155) | 0 (−2 to 9) | 0 (−6 to 13) |
| MRI erosion volume (mm3) | 114 (159.3) | 4.3 (86.8) | 1.2 (165.3) |
| n=50 (baseline), n=39 (6), n=33 (12) | 55 (0 to 760) | 0 (−245 to 424) | 0 (−510 to 763) |
| Ultrasonography erosion score (0–60) | 14 (7.7) | −1.2 (3.9) | −0.1 (4.0) |
| n=47 (baseline), n=39 (6), n=33 (12) | 13 (2 to 35) | −1 (−10 to 6) | −1 (−7 to 10) |
Values are presented as mean (SD) in upper row and median (range) in lower row. Negative delta values indicate a decrease compared with baseline;
↵* p<0.001, compared with baseline;
↵† p<0.001, compared with baseline and p<0.05, compared with 6 months. Because of technical reasons not all patients had all imaging procedures performed successfully, and n denotes the number of patients assessed at each time point. Data on findings on CT and radiography are presented in Møller Døhn et al.30
CRP, C-reactive protein; DAS28, disease activity score in 28 joints; HAQ, health assessment questionnaire.