Cytokines that synergise with interleukin (IL)-17 in rheumatoid arthritis synoviocytes
| Representative target genes | |
|---|---|
| Tumour necrosis factor α | Cytokines (IL-6, GCSF, OSM), |
| Chemokines (CCL20, CXCL1, CXCL2, CXCL5, CCL2, CCL7) | |
| Transcription factors (C/EBPβ, -δ, IκBζ), | |
| Bone remodelling (RANKL, MMP13), | |
| Antimicrobial peptides (LCN2, BD) | |
| Interleukin 1 | IL-6, CXCL8, leukaemia inhibitory factor |
| Interferon γ | IL-6, IL-8 |
BD, Becton Dickinson; CCL, chemokine (C-C motif) ligand; C/EBP, CCAAT/enhancer binding protein; CXCL, chemokine (C-X-C motif) ligand; GCSF, granulocyte colony-stimulating factor; IκB, IkappaB protein; LCN2, lipocalin 2; MMP13, matrix metalloproteinase 13; OSM, oncostatin; RANKL, receptor activator of NF-kappa-B ligand.