Table 2

Cytokines that synergise with interleukin (IL)-17 in rheumatoid arthritis synoviocytes

Representative target genes
Tumour necrosis factor αCytokines (IL-6, GCSF, OSM),
Chemokines (CCL20, CXCL1, CXCL2, CXCL5, CCL2, CCL7)
Transcription factors (C/EBPβ, -δ, IκBζ),
Bone remodelling (RANKL, MMP13),
Antimicrobial peptides (LCN2, BD)
Interleukin 1IL-6, CXCL8, leukaemia inhibitory factor
Interferon γIL-6, IL-8
  • BD, Becton Dickinson; CCL, chemokine (C-C motif) ligand; C/EBP, CCAAT/enhancer binding protein; CXCL, chemokine (C-X-C motif) ligand; GCSF, granulocyte colony-stimulating factor; IκB, IkappaB protein; LCN2, lipocalin 2; MMP13, matrix metalloproteinase 13; OSM, oncostatin; RANKL, receptor activator of NF-kappa-B ligand.