Table 4

Most effective combinations of predictors

Combination of variableNo of patients (% of all)% Treated with MTX
SERO (2+) and HTEND (+) and APR (2+)190 (9.2)73.7
SERO (2+) and HTEND (+) and APR (−/+)184 (8.9)63.0
SERO (+) and HTEND (+) and Wrist (+)120 (5.8)58.3
SERO (−) and Wrist (+) and PIP (+) and APR (2+)105 (5.1)54.3
SERO (+) and HTEND (+) and Wrist (−)101 (4.9)49.5
SERO (2+) and HTEND (−) and MCP (+)65 (3.1)47.7
  • All additional combinations yielded <40% patients actually been treated with methotrexate.

  • –, negative or absent; +, moderately abnormal or present; 2+, highly abnormal (applies only to serology and APR.

  • APR, acute phase response; HTEND, hand tenderness (ie, tenderness of one or more hand region: MCP, PIP, wrist); MCP, metacarpophalangeal joint swelling; MTX, methotrexate; PIP, proximal interphalangeal joint swelling; SERO, serology; Wrist, wrist swelling.