Table 1

Summary of Phase 1 results

VariableComparisonRelative weight
Swollen MCP jointPresent versus absent1.5
Swollen PIP jointPresent versus absent1.5
Swollen wristPresent versus absent1.6
Hand tendernessPresent versus absent1.8
Acute-phase responseLowly abnormal versus normal1.2
Highly abnormal versus normal1.7
Serology (RF or ACPA)Low-positive versus negative2.2
High-positive versus negative3.9
  • Derived from OR from the multivariate regression model, and interpreted as the increase in the odds of having RA with as opposed to without the respective feature (eg, weight of 1.5 for swelling of PIP joints means that the odds of having RA is 1.5-fold in patients with as opposed to patients without swelling of a PIP joint).

  • ACPA, anti-citrullinated protein antibody; MCP, metacarpophalangeal; PIP, proximal interphalangeal; RA, rheumatoid arthritis; RF, rheumatoid factor.