Incidence rates of cardiovascular events by medication exposure
| MI | TIA/stroke | Cardiovascular-related death | Composite cardiovascular events* | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Event | Person years of exposure | Incidence rate (95% CI) | Event | Person years of exposure | Incidence rate (95% CI) | Event | Person years of exposure | Incidence rate (95% CI) | Event | Person years of exposure | Incidence rate (95% CI) | |
| Non-biological DMARDs | 5 | 2.272 | 2.20 (0.27 to 4.13) | 8 | 2.287 | 3.53 (1.09 to 5.97) | 4 | 2.264 | 1.77 (0.04 to 3.50) | 17 | 2.264 | 7.51 (3.95 to 11.07) |
| Methotrexate | 17 | 7.153 | 2.38 (1.26 to 3.51) | 23 | 7.143 | 3.22 (1.91 to 4.53) | 8 | 7.132 | 1.12 (0.35 to 1.90) | 48 | 7.132 | 6.73 (4.83 to 8.63) |
| TNF antagonist | 4 | 7.853 | 0.51 (0.01 to 1.01) | 14 | 7.841 | 1.79 (0.85, 2.72) | 5 | 7.837 | 1.02 (0.31 to 1.73) | 23 | 7.837 | 2.93 (1.74 to 4.13) |
Incidence rates expressed per 1000 patient years of exposure.
↵* Composite includes myocardial infarction (MI), transient ischaemic attack (TIA)/stroke and cardiovascular-related deaths.
DMARDs, disease-modifying antirheumatic drugs; TNF, tumour necrosis factor.