Recognition of individual citrullinated peptides before and after disease onset
| Peptide | Pre-RA (n=36) n (%) | RA (n=36) n (%) | Lost reactivity | Gained reactivity | p Value McNemar |
|---|---|---|---|---|---|
| CCP2 | 21 (58) | 29 (81) | 2 | 10 | 0.039 |
| Vimentin 1–16 | 3 (8.1) | 1 (2.7) | 3 | 1 | 0.63 |
| Vimentin 59–74 | 10 (27) | 14 (38) | 4 | 8 | 0.39 |
| Fibrinogen α 27–43 | 2 (5.6) | 7 (19) | 0 | 5 | 0.062 |
| Fibrinogen β 36–52 | 9 (25) | 15 (42) | 4 | 10 | 0.18 |
| Enolase 5–20 | 4 (11) | 9 (25) | 1 | 6 | 0.13 |
| Recognition of ≥1 peptides | 14 (38) | 24 (66) | 2 | 12 | 0.013 |
CCP2, cyclic citrullinated peptide-2; RA, rheumatoid arthritis.