Meta-analysis results for AutoCure samples—GRACE collection including EIRA control data
| SNP | Gene | Case/control | MAF case | MAF control | Het p | χ2 p | OR (95% CI) |
|---|---|---|---|---|---|---|---|
| rs231775 | CTLA4 | 2272/3317 | 0.37 | 0.38 | 0.071 | 0.647 | 1.02 (0.94 to 1.11) |
| rs743777 | IL2RB | 3068/4048 | 0.33 | 0.32 | 0.086 | 0.408 | 1.07 (0.91 to 1.26) |
| rs763361 | CD226 | 3152/3992 | 0.49 | 0.47 | 0.782 | 0.396 | 1.03 (0.96 to 1.11) |
| rs1160542 | AFF3 | 3146/4062 | 0.49 | 0.47 | 0.854 | 0.029 | 1.08 (1.01 to 1.16) |
| rs1678542 | KIF5A | 3144/4065 | 0.36 | 0.38 | 0.073 | 0.023 | 0.92 (0.86 to 0.99) |
| rs2104286 | IL2RA | 3149/4066 | 0.24 | 0.26 | 0.898 | 0.115 | 0.94 (0.86 to 1.01) |
| rs2476601 | PTPN22 | 2794/4194 | 0.15 | 0.10 | 0.010 | 6.25e-12 | 1.48 (1.33 to 1.66) |
| rs2812378 | CCL21 | 3146/4062 | 0.35 | 0.33 | 0.187 | 0.251 | 1.04 (0.97 to 1.13) |
| rs2900180 | TRAF1/C5 | 3147/4223 | 0.36 | 0.35 | 0.095 | 0.057 | 1.07 (0.99 to 1.15) |
| rs3087243 | CTLA4 | 3058/4279 | 0.42 | 0.44 | 0.279 | 0.024 | 0.92 (0.86 to 0.99) |
| rs4750316 | PRKCQ | 3075/4046 | 0.18 | 0.19 | 0.525 | 0.501 | 0.97 (0.86 to 1.06) |
| rs4810485 | CD40 | 3043/4044 | 0.24 | 0.25 | 0.010 | 0.033 | 0.91 (0.84 to 0.99) |
| rs5029937 | 6q23 | 2262/3379 | 0.04 | 0.03 | 0.166 | 0.002 | 1.40 (1.13 to 1.74) |
| rs6822844 | IL2/IL21 | 3143/3998 | 0.16 | 0.16 | 0.329 | 0.656 | 0.98 (0.89 to 1.07) |
| rs6920220 | 6q23 | 3146/4066 | 0.21 | 0.21 | 0.479 | 0.093 | 1.08 (0.99 to 1.17) |
| rs7574865 | STAT4 | 3063/4198 | 0.25 | 0.22 | 0.030 | 0.0003 | 1.17 (1.07 to 1.27) |
| rs10760130 | TRAF1/C5 | 3155/4254 | 0.45 | 0.43 | 0.348 | 0.035 | 1.08 (1.01 to 1.16) |
| rs13207033 | 6q23 | 2984/4042 | 0.26 | 0.26 | 0.153 | 0.348 | 0.96 (0.89 to 1.04) |
χ2 p, χ2 p value; Het p, heterogeneity χ2 p value; EIRA, Epidemiological Investigation of Rheumatoid Arthritis; GRACE, Genetic Repository for AutoCure; MAF, minor allele frequency; SNP, single-nucleotide polymorphism.