Table 2

RA linkage study for the IRF5 rs3757385 C, rs2004640 T and rs10954213 A alleles according to bone erosion and RF status of RA index cases

	IRF5 rs3757385					IRF5 rs2004640					IRF5 rs10954213
RA index cases	Tr	Un	T (%)	p Value	p_adj	Tr	Un	T (%)	p Value	p_adj	Tr	Un	T (%)	p Value	p_adj
Global sample, n=380	195	139	58.4	0.0022		219	159	57.9	0.0020		203	156	56.5	0.013
RF-positive, n=282	137	108	55.9	0.06	–	153	119	56.3	0.039	0.31	137	122	52.9	0.23	–
RF-negative, n=98	58	31	65.2	0.0042	0.034	66	40	62.3	0.011	0.088	66	34	66.0	0.0014	0.011
Erosive, n=285	138	111	55.4	0.09	–	151	120	55.7	0.06	–	138	124	52.7	0.39	–
Non-erosive, n=95	57	28	67.1	0.0017	0.014	68	39	63.6	0.0051	0.041	65	32	67.0	8.04×10⁻⁴	0.0064

p_adj, p<0.05 adjusted after Bonferonni's correction for multiple testing.
RF, rheumatoid factor; RA, rheumatoid arthritis; T, transmission; Tr, transmitted, Un, untransmitted.