Risk of radiographic progression of hand osteoarthritis over 6 years for tertiles of baseline determinants and hand osteoarthritis subsets
| Risk ratio (95% CI) | |||
|---|---|---|---|
| Radiographic progression (n=236) | Crude | Adjusted* | |
| Self-reported pain | |||
| <4 | 23/60 | 1 | 1 |
| 4–8 | 38/78 | 1.27 (0.86 to 1.69) | 1.28 (0.84 to 1.74) |
| >8 | 50/80 | 1.63 (1.21 to 1.99) | 1.62 (1.14 to 2.02) |
| Self-reported function | |||
| <7 | 33/76 | 1 | 1 |
| 7–16 | 38/75 | 1.17 (0.80 to 1.52) | 1.23 (0.85 to 1.60) |
| >16 | 40/67 | 1.37 (1.00 to 1.71) | 1.33 (0.95 to 1.73) |
| No. of painful joints | |||
| <4 | 30/78 | 1 | 1 |
| 4–8 | 48/76 | 1.64 (1.24 to 1.98) | 1.63 (1.19 to 2.00) |
| >8 | 46/82 | 1.46 (1.05 to 1.84) | 1.34 (0.90 to 1.77) |
| Pain intensity | |||
| <1 | 24/72 | 1 | 1 |
| 1–4 | 56/90 | 1.87 (1.39 to 2.28) | 1.80 (1.31 to 2.24) |
| >4 | 44/74 | 1.78 (1.28 to 2.23) | 1.70 (1.18 to 2.19) |
| No. of nodes | |||
| <6 | 22/79 | 1 | 1 |
| 6–11 | 51/78 | 2.35 (1.80 to 2.81) | 2.06 (1.47 to 2.60) |
| >11 | 51/79 | 2.32 (1.71 to 2.81) | 1.84 (1.19 to 2.48) |
| Osteophytes | |||
| <6 | 27/71 | 1 | 1 |
| 6–11 | 40/87 | 1.21 (0.83 to 1.61) | 1.28 (0.87 to 1.70) |
| >11 | 57/78 | 1.92 (1.51 to 2.22) | 1.86 (1.38 to 2.21) |
| JSN | |||
| <14 | 38/75 | 1 | 1 |
| 14–22 | 33/86 | 0.74 (0.47 to 1.06) | 0.71 (0.45 to 1.05) |
| >22 | 53/75 | 1.47 (1.10 to 1.78) | 1.24 (0.82 to 1.63) |
| Hand OA subsets | |||
| Erosive hand OA | 30/35 | 1.83 (1.50 to 2.01) | 1.55 (1.04 to 1.88) |
| Nodal hand OA | 104/164 | 2.28 (1.74 to 2.74) | 1.94 (1.37 to 2.48) |
| Thumb base OA | 64/109 | 1.18 (0.96 to 1.36) | 1.16 (0.91 to 1.36) |
↵* Adjusted for baseline osteophyte and joint space narrowing scores, follow-up time and family effects.
JSN, joint space narrowing; OA, osteoarthritis.