Table 4

Risk of poor clinical outcome of hand osteoarthritis on self-reported pain and functional limitations defined as not fulfilling the Patient Acceptable Symptom State after 6 years, for tertiles of baseline determinants and hand osteoarthritis subsets

Risk ratio (95% CI)Risk ratio (95% CI)
Poor outcome pain (n=271)CrudeAdjusted*Poor outcome function (n=271)CrudeAdjusted*
Self-reported pain
 <410/76119/7611
 4–834/982.64 (1.56 to 3.97)2.57 (1.50 to 3.91)28/982.41 (1.34 to 3.87)1.38 (0.57 to 2.93)
 >873/975.72 (4.38 to 6.63)5.74 (4.38 to 6.65)71/976.18 (4.69 to 7.23)3.56 (1.63 to 5.83)
Self-reported function
 <714/891110/8911
 7–1641/982.66 (1.68 to 3.75)1.60 (0.80 to 2.79)33/983.00 (1.64 to 4.74)2.97 (1.61 to 4.72)
 >1662/844.69 (3.63 to 5.45)2.57 (1.26 to 4.13)65/846.89 (5.31 to 7.90)6.88 (5.30 to 7.90)
No. of painful joints
 <419/931118/9311
 4–837/892.03 (1.33 to 2.82)1.43 (0.79 to 2.31)30/891.74 (1.09 to 2.54)1.39 (0.75 to 2.28)
 >861/893.36 (2.62 to 3.94)2.11 (1.25 to 3.08)60/893.48 (2.69 to 4.12)2.39 (1.47 to 3.37)
Pain intensity
 <120/801118/8011
 1–439/1011.55 (1.01 to 2.17)0.92 (0.47 to 1.60)34/1011.50 (0.92 to 2.20)0.83 (0.39 to 1.58)
 >458/902.58 (1.98 to 3.08)1.24 (0.68 to 1.99)56/902.76 (2.05 to 3.38)1.46 (0.77 to 2.37)
No. of nodes
 <626/861125/8611
 6–1145/981.52 (1.03 to 2.04)1.29 (0.75 to 1.91)43/981.51 (1.02 to 2.04)1.06 (0.59 to 1.72)
 >1146/871.75 (1.22 to 2.26)1.44 (0.91 to 2.02)40/871.58 (1.07 to 2.12)0.98 (0.56 to 1.57)
Osteophytes
 <629/841131/8411
 6–1137/951.13 (0.76 to 1.54)0.93 (0.59 to 1.36)35/951.00 (0.66 to 1.39)0.75 (0.43 to 1.21)
 >1148/891.56 (1.14 to 1.97)1.22 (0.77 to 1.73)40/891.22 (0.83 to 1.62)0.72 (0.40 to 1.19)
JSN
 <1436/891135/8911
 14–2233/920.88 (0.59 to 1.24)0.72 (0.42 to 1.12)32/920.88 (0.57 to 1.25)0.59 (0.32 to 1.01)
 >2245/871.28 (0.93 to 1.62)1.02 (0.64 to 1.46)39/871.14 (0.79 to 1.51)0.79 (0.45 to 1.23)
Hand OA subsets
 Erosive hand OA23/371.58 (1.13 to 1.96)1.12 (0.56 to 1.73)21/371.54 (1.10 to 1.95)1.14 (0.75 to 1.59)
 Nodal hand OA92/1911.54 (1.10 to 1.99)1.25 (0.82 to 1.74)81/1911.26 (0.87 to 1.68)0.80 (0.46 to 1.29)
 Thumb base OA68/1251.62 (1.24 to 1.99)0.92 (0.56 to 1.38)71/1252.24 (1.69 to 2.76)1.50 (0.95 to 2.15)
  • * Adjusted for baseline scores of the clinical outcome measure, follow-up time and family effects.

  • JSN, joint space narrowing; OA, osteoarthritis.