Risk of poor clinical outcome of hand osteoarthritis on self-reported pain and functional limitations defined as not fulfilling the Patient Acceptable Symptom State after 6 years, for tertiles of baseline determinants and hand osteoarthritis subsets
| Risk ratio (95% CI) | Risk ratio (95% CI) | |||||
|---|---|---|---|---|---|---|
| Poor outcome pain (n=271) | Crude | Adjusted* | Poor outcome function (n=271) | Crude | Adjusted* | |
| Self-reported pain | ||||||
| <4 | 10/76 | 1 | 1 | 9/76 | 1 | 1 |
| 4–8 | 34/98 | 2.64 (1.56 to 3.97) | 2.57 (1.50 to 3.91) | 28/98 | 2.41 (1.34 to 3.87) | 1.38 (0.57 to 2.93) |
| >8 | 73/97 | 5.72 (4.38 to 6.63) | 5.74 (4.38 to 6.65) | 71/97 | 6.18 (4.69 to 7.23) | 3.56 (1.63 to 5.83) |
| Self-reported function | ||||||
| <7 | 14/89 | 1 | 1 | 10/89 | 1 | 1 |
| 7–16 | 41/98 | 2.66 (1.68 to 3.75) | 1.60 (0.80 to 2.79) | 33/98 | 3.00 (1.64 to 4.74) | 2.97 (1.61 to 4.72) |
| >16 | 62/84 | 4.69 (3.63 to 5.45) | 2.57 (1.26 to 4.13) | 65/84 | 6.89 (5.31 to 7.90) | 6.88 (5.30 to 7.90) |
| No. of painful joints | ||||||
| <4 | 19/93 | 1 | 1 | 18/93 | 1 | 1 |
| 4–8 | 37/89 | 2.03 (1.33 to 2.82) | 1.43 (0.79 to 2.31) | 30/89 | 1.74 (1.09 to 2.54) | 1.39 (0.75 to 2.28) |
| >8 | 61/89 | 3.36 (2.62 to 3.94) | 2.11 (1.25 to 3.08) | 60/89 | 3.48 (2.69 to 4.12) | 2.39 (1.47 to 3.37) |
| Pain intensity | ||||||
| <1 | 20/80 | 1 | 1 | 18/80 | 1 | 1 |
| 1–4 | 39/101 | 1.55 (1.01 to 2.17) | 0.92 (0.47 to 1.60) | 34/101 | 1.50 (0.92 to 2.20) | 0.83 (0.39 to 1.58) |
| >4 | 58/90 | 2.58 (1.98 to 3.08) | 1.24 (0.68 to 1.99) | 56/90 | 2.76 (2.05 to 3.38) | 1.46 (0.77 to 2.37) |
| No. of nodes | ||||||
| <6 | 26/86 | 1 | 1 | 25/86 | 1 | 1 |
| 6–11 | 45/98 | 1.52 (1.03 to 2.04) | 1.29 (0.75 to 1.91) | 43/98 | 1.51 (1.02 to 2.04) | 1.06 (0.59 to 1.72) |
| >11 | 46/87 | 1.75 (1.22 to 2.26) | 1.44 (0.91 to 2.02) | 40/87 | 1.58 (1.07 to 2.12) | 0.98 (0.56 to 1.57) |
| Osteophytes | ||||||
| <6 | 29/84 | 1 | 1 | 31/84 | 1 | 1 |
| 6–11 | 37/95 | 1.13 (0.76 to 1.54) | 0.93 (0.59 to 1.36) | 35/95 | 1.00 (0.66 to 1.39) | 0.75 (0.43 to 1.21) |
| >11 | 48/89 | 1.56 (1.14 to 1.97) | 1.22 (0.77 to 1.73) | 40/89 | 1.22 (0.83 to 1.62) | 0.72 (0.40 to 1.19) |
| JSN | ||||||
| <14 | 36/89 | 1 | 1 | 35/89 | 1 | 1 |
| 14–22 | 33/92 | 0.88 (0.59 to 1.24) | 0.72 (0.42 to 1.12) | 32/92 | 0.88 (0.57 to 1.25) | 0.59 (0.32 to 1.01) |
| >22 | 45/87 | 1.28 (0.93 to 1.62) | 1.02 (0.64 to 1.46) | 39/87 | 1.14 (0.79 to 1.51) | 0.79 (0.45 to 1.23) |
| Hand OA subsets | ||||||
| Erosive hand OA | 23/37 | 1.58 (1.13 to 1.96) | 1.12 (0.56 to 1.73) | 21/37 | 1.54 (1.10 to 1.95) | 1.14 (0.75 to 1.59) |
| Nodal hand OA | 92/191 | 1.54 (1.10 to 1.99) | 1.25 (0.82 to 1.74) | 81/191 | 1.26 (0.87 to 1.68) | 0.80 (0.46 to 1.29) |
| Thumb base OA | 68/125 | 1.62 (1.24 to 1.99) | 0.92 (0.56 to 1.38) | 71/125 | 2.24 (1.69 to 2.76) | 1.50 (0.95 to 2.15) |
↵* Adjusted for baseline scores of the clinical outcome measure, follow-up time and family effects.
JSN, joint space narrowing; OA, osteoarthritis.