Table 1

Bone resorption indices after pamidronate (PAM) in meniscectomised Runx2-Tg and wild-type (WT) mice

WTWT+PAMRunx-2-TgRunx2-Tg+PAM
N.OC/BV25.41±3.675.19±1.04*65.55±7.1913.74±3.27§
Tb.N (/mm)0.008±0.0010.02±0.001*0.007±0.0010.015±0.002§
Tb.Th (µm)23.55±0.9322.98±1.8721.92±1.3220.91±1.58
Tb.Sp (µm)103.15±10.7529.35±3.62*124.5±11.4347.09±8.17§
  • Bone micro-architectural indices and the osteoclast number were measured in meniscectomy-tibial epiphysis of WT and Runx2-Tg mice in the presence or absence of PAM.

  • * Significant difference between WT mice receiving phosphate-buffered saline (PBS) and WT mice receiving PAM, p<0.01;

  • significant difference between WT and Runx2-Tg mice receiving PBS, p<0.05;

  • significant difference between Runx2-Tg mice receiving PBS and Runx2-Tg mice receiving PAM, p<0.05;

  • § significant difference between WT and Runx2-Tg mice receiving PAM, p<0.05.

  • BV, bone volume; N.OC, osteoclast number; Tb.N, trabecular number; Tb.Sp, trabecular separation; Tb.Th, trabecular thickness.