Responsiveness of clinical, biochemical and imaging measures of disease activity from week 0 to 22
| Measure of disease activity | Mean (SD) at week 0 (n=60) | Mean (SD) change from week 0 to week 22 (n=53) | ES (n=53) | SRM (n=53) |
|---|---|---|---|---|
| ASDAS | 3.9 (0.97) | 2.0 (1.4) | 2.04 | 1.45 |
| BASDAI (0–100) | 57.3 (17.5) | 32.6 (23.7) | 1.86 | 1.36 |
| Fatigue (0–100 mm) | 64.7 (20.2) | 34.4 (25.9) | 1.70 | 1.32 |
| Patient's global (0–100 mm) | 64.9 (21.0) | 35.6 (28.0) | 1.69 | 1.27 |
| Pain (0–100 mm) | 61.2 (22.0) | 36.9 (30.1) | 1.67 | 1.20 |
| Physician's global (0–100 mm) | 43.1 (19.1) | 27.3 (19.2) | 1.43 | 1.42 |
| BASFI (0–100) | 51.8 (20.4) | 23.8 (22.4) | 1.16 | 1.06 |
| Serum CRP (mg/l) | 27.3 (33.5) | 21.3 (30.4) | 0.63 | 0.70 |
| BASMI (0–100) | 36.2 (18.9) | 11.7 (14.0) | 0.62 | 0.83 |
| MASES (0–13) | 3.2 (3.5) | 2.1 (3.1) | 0.60 | 0.69 |
| Berlin MRI lumbar spine IS (0–15) | 1.7 (2.2) | 1.1 (1.7) | 0.66 | 0.51 |
| Berlin MRI total IS (0–47) | 8.5 (7.4) | 2.6 (7.6) | 0.35 | 0.36 |
| Berlin MRI SIJ IS (0–32) | 6.9 (6.3) | 1.4 (6.3) | 0.22 | 0.22 |
| Berlin MRI SIJ CS (0–8) | 6.5 (1.7) | 0.1 (0.7) | – | – |
| Tender joint count (0–28) | 1.7 (4.0) | 1.4 (3.6) | – | – |
| Swollen joint count (0–28) | 0.9 (2.3) | 0.7 (2.2) | – | – |
The results are ranked according to effect size (ES). The 53 patients who completed week 22 were included in the analyses, except for ASDAS where data were available for only 47 patients. Tender and swollen joint counts and the Berlin MRI SIJ chronicity score showed extremely skewed distributions and were omitted from the analysis of ES and SRM.
AS, ankylosing spondylitis; ASDAS, Ankylosing Spondylitis Disease Activity Score; BASDAI, Bath Ankylosing Spondylitis Disease Activity Index; BASFI, Bath Ankylosing Spondylitis Functional Index; BASMI, Bath Ankylosing Spondylitis Metrology Index; CRP, C-reactive protein; CS, chronicity score; ES, effect size; IS, inflammation score; MASES, Maastricht Ankylosing Spondylitis Enthesitis Score; SIJ, sacroiliac joints; SRM, standardised response mean.