Table 1

Demographic characteristics, antinuclear antibody (ANA) pattern and the presence of specific autoantibodies in the patients with systemic sclerosis (SSc) (n=70)*

Age (mean (range), years)60 (19–93)
Gender (M/F)13/57 (19/81)
Disease duration (mean, (range), years)9 (0–34)
ESR (mean (range))19.7 (2–110)
Limited SSc54 (77)
Diffuse SSc16 (23)
Raynaud's phenomenon66 (94)
History of digital ulcers43 (61)
Digital loss5 (7)
Gastrointestinal involvement61 (87)
Lung fibrosis23/68 (34)
Cardiac involvement27 (39)
Pulmonary hypertension16/59 (27)
History of peripheral thrombosis6 (9)
History of scleroderma renal crisis2 (3)
Any ANA pattern55 (79)
Centromere24 (34)
Homogeneous10 (14)
Nucleolar13 (19)
Speckled10 (14)
Specific autoantibodies43 (61)
Anti-CENP-B25 (36)
Anti-RNP10 (14)
Anti-Topo-I9 (13)
Anti-SSA7 (10)
Anti-Jo-12 (3)
  • * Except where indicated otherwise, values are the number (%) of patients.

  • Data only available from 67, 68 and 59 patients for erythrocyte sedimentation rate (ESR), lung fibrosis and pulmonary hypertension, respectively.

  • Antinuclear antibodies (ANA) detected by indirect immunofluorescence microscopy on HEp-2 cells

  • CENP-B, centromere protein B; Jo-1, histidyl tRNA-synthetase; RNP, ribonucleic protein; SSA, Sjögren's syndrome antigen; Topo-I, topoisomerase-I.