Table 2

Factors associated with mortality within the first year after trial entry on univariable analysis based on Kaplan–Meier and Cox regression proportional hazards approaches

Factor	Hazard ratio (95% CI)	p Value
Univariable analysis
Weighted infection burden score	1.2 (1.2 to 1.2)^*	<0.001
Weighted leucopenia burden score	1.2 (1.1 to 1.2)^*	<0.001
Weighted adverse event (other) burden score	1.3 (1.2 to 1.5)^*	<0.001
Vasculitis type		<0.001
MPA	4.2 (2.3 to 7.7)^†
Renal limited	1.3 (0.4 to 4.5)^†
Age	1.9 (1.4 to 2.5)^‡	<0.001
GFR		<0.001
<15 ml/min	13.6 (4.2 to 43.8)^§
15–60 ml/min	2.5 (0.7 to 9.3)^§
CRP	1.03 (0.9 to 1.1)^¶	0.06
BVAS		0.07
<14	0.5 (0.2 to 0.9)^**
15–21	0.6 (0.3 to 1.1)^**
Vasculitis relapse	0.3 (0.2 to 1.2)^††	0.1
Gender	1.2 (0.7 to 2.0)^‡‡	0.48
Final VDI	1.0 (0.7 to 1.4)^*	0.87
Multivariable analysis
Weighted infection burden score	1.2 (1.1 to 1.23)^*	<0.001
Weighted adverse event burden score	1.3 (1.1 to 1.4)^*	<0.001
Weighted leucopenia burden score	1.2 (1.1 to 1.2)^*	<0.001
GFR	0.7 (0.6 to 0.9)^§	0.002
Cumulative cyclophosphamide dose (time-dependent covariate)	1.2 (1.05 to 1.4)^§§	0.04

Hazard ratios for each variable were derived using Cox regression. Age, vasculitis type, Birmingham vasculitis activity score (BVAS), relapse and C-reactive protein (CRP) were not independently associated with one-year mortality on multivariable analysis.
↵* For every 1-point rise;
↵† Relative to Wegener's granulomatosis;
↵‡ For every decade increase;
↵§ Relative to >60 ml/min;
↵¶ For every 10-point rise in CRP;
↵** Relative to >21;
↵†† Yes vs no;
↵‡‡ Female versus male;
↵§§ For every gram increase.
GFR, glomerular filtration rate; MPA, microscopic polyangiitis; VDI, vasculitis damage index.