Table 1

Study specific and meta-analyses by allele frequency data of SNP within the genes that modify D2 actions for cases with knee, hip or hand osteoarthritis

Gene	SNP	Dutch, GARP				UK				Spain				Greece				Meta-analyses
		OR^*	L95	R95	p Value	OR^*	L95	R95	p Value	OR^*	L95	R95	p Value	OR^*	L95	R95	p Value	OR^*	L95	U95	P1^†	P2^‡
DIO3	rs1190715	0.86	0.72	1.04	0.124	0.93	0.83	1.05	0.242	1.03	0.84	1.28	0.768	0.98	0.72	1.34	0.896	0.94	0.86	1.02	0.1364	0.8732
	rs8011440	0.85	0.70	1.03	0.102	1.06	0.94	1.20	0.317	1.15	0.92	1.43	0.226	1.12	0.88	1.43	0.367	1.04	0.95	1.13	0.4410	0.9997
	rs945006	0.74	0.51	1.08	0.119^§	0.85	0.71	1.03	0.093	0.71	0.52	0.99	0.040	1.00	0.68	1.48	0.999	0.83	0.72	0.95	0.0068^§	0.0625
IHH	rs1378640	1.14	0.92	1.43	0.229	1.00	0.87	1.14	0.944	0.88	0.69	1.11	0.266	0.89	0.68	1.18	0.423	0.99	0.89	1.09	0.7893	1.0000
	rs3100776	1.21	0.76	1.95	0.424	1.12	0.81	1.55	0.493	0.84	0.50	1.40	0.495	0.97	0.45	2.08	0.933	1.07	0.85	1.34	0.5840	1.0000
	rs3731878	1.21	0.90	1.63	0.203	0.97	0.80	1.18	0.779	1.39	0.98	1.98	0.069	1.23	0.83	1.84	0.303	1.11	0.97	1.28	0.1304	0.8607
	rs3731881	1.21	1.00	1.47	0.054	0.99	0.87	1.12	0.846	1.05	0.84	1.30	0.667	0.99	0.77	1.28	0.950	1.04	0.95	1.14	0.3807	0.9987
THRA	rs1568400	1.19	0.97	1.47	0.102	1.00	0.88	1.15	0.944	1.06	0.84	1.34	0.610	0.94	0.72	1.22	0.627	1.04	0.95	1.14	0.4132	0.9994
	rs3744805	0.80	0.60	1.06	0.123	0.99	0.82	1.19	0.884	1.04	0.73	1.47	0.839	0.95	0.60	1.50	0.825	0.94	0.82	1.08	0.3930	0.9990
	rs939348	0.88	0.72	1.09	0.244	0.96	0.84	1.09	0.524	1.06	0.83	1.36	0.623	0.82	0.57	1.18	0.285	0.95	0.86	1.04	0.2663	0.9865
USP33	rs11162380	0.92	0.74	1.15	0.485	0.94	0.82	1.07	0.346	1.38	1.10	1.75	0.006	0.81	0.63	1.04	0.095	0.98	0.89	1.08	0.6567	1.0000
	rs12030080	0.95	0.65	1.39	0.802	0.82	0.64	1.05	0.114	0.98	0.63	1.52	0.932	0.99	0.66	1.49	0.963	0.90	0.76	1.07	0.2155	0.9665
	rs12121287	1.12	0.82	1.51	0.476	0.91	0.74	1.11	0.342	1.25	0.90	1.74	0.177	1.03	0.75	1.41	0.845	1.02	0.90	1.17	0.7345	1.0000
	rs2147318	0.89	0.71	1.13	0.349	0.91	0.79	1.05	0.202	1.33	1.05	1.68	0.018	0.78	0.61	1.00	0.051	0.95	0.86	1.05	0.3025	0.9935
WSB1	rs4795552	1.03	0.85	1.25	0.734	0.94	0.83	1.06	0.295	1.16	0.93	1.44	0.194	0.78	0.61	0.99	0.041	0.97	0.89	1.05	0.4179	0.9995
	rs6505204	1.00	0.83	1.21	0.972	0.96	0.86	1.09	0.554	1.21	0.98	1.50	0.074	0.81	0.64	1.03	0.086	0.99	0.91	1.07	0.7572	1.0000
	rs7213148	0.86	0.44	1.67	0.649	0.96	0.67	1.38	0.819	2.76	1.09	7.01	0.033	1.63	0.90	2.94	0.105	1.18	0.91	1.54	0.2155	0.9665

↵* OR and p values presented were calculated by PLINK13 for the allelic model and presented with the minor allele (as indicated in supplementary table 2, available online only) as the risk allele.
↵† P1, empirical p value using Cochran--Mantel--Haenszel statistics as implemented in PLINK.13
↵‡ P2, statistical significance determined by max (T) permutation as implemented in PLINK to adjust for the multiplicity of testing the 17 single nucleotide polymorphisms (SNP) genotyped in the four cohorts. This is achieved by comparing each test statistic against the maximum of all permuted SNP statistics.
↵§ p Value adjusted for family relationships among the sibling-pairs of the Dutch Genetics Osteoarthritis and Progression (GARP) study by estimating the standard errors in Stata SE8 software from the variance between the sibling pairs (robust standard errors).14
DIO3, deiodinase iodothyronine type III; IHH, Indian hedgehog; L95, 95% left boundary of the CI; R95, right boundary of the 95% CI; THRA, thyroid hormone receptor α; USP33, ubiquitin-specific protease 33; WSB1, WD40-repeat/SOCS-box protein 1.