Table 1

Study specific and meta-analyses by allele frequency data of SNP within the genes that modify D2 actions for cases with knee, hip or hand osteoarthritis

GeneSNPDutch, GARPUKSpainGreeceMeta-analyses
OR*L95R95p ValueOR*L95R95p ValueOR*L95R95p ValueOR*L95R95p ValueOR*L95U95P1P2
DIO3rs11907150.860.721.040.1240.930.831.050.2421.030.841.280.7680.980.721.340.8960.940.861.020.13640.8732
rs80114400.850.701.030.1021.060.941.200.3171.150.921.430.2261.120.881.430.3671.040.951.130.44100.9997
rs9450060.740.511.080.119§0.850.711.030.0930.710.520.990.0401.000.681.480.9990.830.720.950.0068§0.0625
IHHrs13786401.140.921.430.2291.000.871.140.9440.880.691.110.2660.890.681.180.4230.990.891.090.78931.0000
rs31007761.210.761.950.4241.120.811.550.4930.840.501.400.4950.970.452.080.9331.070.851.340.58401.0000
rs37318781.210.901.630.2030.970.801.180.7791.390.981.980.0691.230.831.840.3031.110.971.280.13040.8607
rs37318811.211.001.470.0540.990.871.120.8461.050.841.300.6670.990.771.280.9501.040.951.140.38070.9987
THRArs15684001.190.971.470.1021.000.881.150.9441.060.841.340.6100.940.721.220.6271.040.951.140.41320.9994
rs37448050.800.601.060.1230.990.821.190.8841.040.731.470.8390.950.601.500.8250.940.821.080.39300.9990
rs9393480.880.721.090.2440.960.841.090.5241.060.831.360.6230.820.571.180.2850.950.861.040.26630.9865
USP33rs111623800.920.741.150.4850.940.821.070.3461.381.101.750.0060.810.631.040.0950.980.891.080.65671.0000
rs120300800.950.651.390.8020.820.641.050.1140.980.631.520.9320.990.661.490.9630.900.761.070.21550.9665
rs121212871.120.821.510.4760.910.741.110.3421.250.901.740.1771.030.751.410.8451.020.901.170.73451.0000
rs21473180.890.711.130.3490.910.791.050.2021.331.051.680.0180.780.611.000.0510.950.861.050.30250.9935
WSB1rs47955521.030.851.250.7340.940.831.060.2951.160.931.440.1940.780.610.990.0410.970.891.050.41790.9995
rs65052041.000.831.210.9720.960.861.090.5541.210.981.500.0740.810.641.030.0860.990.911.070.75721.0000
rs72131480.860.441.670.6490.960.671.380.8192.761.097.010.0331.630.902.940.1051.180.911.540.21550.9665
  • * OR and p values presented were calculated by PLINK13 for the allelic model and presented with the minor allele (as indicated in supplementary table 2, available online only) as the risk allele.

  • P1, empirical p value using Cochran--Mantel--Haenszel statistics as implemented in PLINK.13

  • P2, statistical significance determined by max (T) permutation as implemented in PLINK to adjust for the multiplicity of testing the 17 single nucleotide polymorphisms (SNP) genotyped in the four cohorts. This is achieved by comparing each test statistic against the maximum of all permuted SNP statistics.

  • § p Value adjusted for family relationships among the sibling-pairs of the Dutch Genetics Osteoarthritis and Progression (GARP) study by estimating the standard errors in Stata SE8 software from the variance between the sibling pairs (robust standard errors).14

  • DIO3, deiodinase iodothyronine type III; IHH, Indian hedgehog; L95, 95% left boundary of the CI; R95, right boundary of the 95% CI; THRA, thyroid hormone receptor α; USP33, ubiquitin-specific protease 33; WSB1, WD40-repeat/SOCS-box protein 1.