Non-switchers (n=437) | Switchers (n=77) | |||||
---|---|---|---|---|---|---|

1st TNFi | 1st TNFi | 2nd TNFi | ||||

3 Months | 3 Months | Last observation^{†} | 3 Months | p Value^{‡} | p Value^{§} | |

(n=362) | (n=63) | (n=68) | (n=62) | |||

BASDAI 50, n (%) | 105 (50.0) | 6 (25.0) | 2 (22.2) | 13 (28.3) | 0.007 | 1.00 |

n=202 | n=23 | n=25 | n=45 | |||

ASAS20, n (%) | 106 (52.5) | 11 (47.8) | 7 (28.0) | 18 (40.0) | 0.13 | 1.00 |

ASAS40, n (%) | 76 (37.6) | 7 (30.4) | 4 (16.7) | 14 (31.1) | 0.41 | 1.00 |

n=168 | n=19 | n=22 | n=35 | |||

ΔASDAS ≥1.1 (Clinically Important Improvement), n (%) | 94 (56.0) | 11 (57.9) | 8 (36.4) | 17 (48.6) | 0.42 | 1.00 |

ΔASDAS ≥2.0 (Major Improvement), n (%) | 51 (30.4) | 2 (10.5) | 2 (9.1) | 11 (31.4) | 0.90 | 0.38 |

* BASDAI 50, ASAS and ASDAS responses were not available for all patients (see details in text).

↵† 3 months, n=17; 6 months, n=24; 1 year, n=9; 2 years, n=10; 3 years, n=3; 4 years, n=2.

↵‡ Non-switchers first TNFi vs switchers second TNFi (χ

^{2}test).↵§ Switchers first TNFi (3 months) vs switchers second TNFi (McNemar test).

ASAS, Assessments of Spondyloarthritis International Society; ASDAS, Ankylosing Spondylitis Disease Activity Score; BASDAI, Bath Ankylosing Spondylitis Disease Activity Index; TNFi, tumour necrosis factor inhibitor.