Table 2

Validation of 6MWT in PAH-SSc according to the OMERACT filter

OMERACT filter criterionValidationHighest quality of PAH definition
Truth
 Face validityVNA
 Content validityNVC1
 Criterion validityNDNo studies
 Construct validityPVA1
Discrimination
 Sensitivity to change over timePVA1 (placebo groups)
 Discrimination capacity in response to therapyVA1
 Reliability (reproducibility)PVStudies in SSc-ILD
FeasibilityVA1
  • V, valid: a criterion was judged validated if appropriate information was available from studies including exclusively patients with PAH-SSc (quality definition A1, see table 1 for details). Exception is face validity, which is evaluated by the judgement of experts as an appropriate measure rather than by specific studies. NV, not valid: similarly, a criterion was judged not valid if appropriate information was available from studies including exclusively patients with PAH-SSc (quality definition A1, see table 1 for details). PV, partially validated: a criterion was judged partially validated if data from studies lower than quality level A1 indicated that the criterion is validated.

  • 6MWT, 6 min walk test; NA, not applicable; ND, no data; PAH, pulmonary arterial hypertension; PAH-SSc, pulmonary arterial hypertension secondary to systemic sclerosis.