OMERACT filter criterion | Validation | Highest quality of PAH definition |
---|---|---|
Truth | ||
Face validity | V | NA |
Content validity | NV | C1 |
Criterion validity | ND | No studies |
Construct validity | PV | A1 |
Discrimination | ||
Sensitivity to change over time | PV | A1 (placebo groups) |
Discrimination capacity in response to therapy | V | A1 |
Reliability (reproducibility) | PV | Studies in SSc-ILD |
Feasibility | V | A1 |
V, valid: a criterion was judged validated if appropriate information was available from studies including exclusively patients with PAH-SSc (quality definition A1, see table 1 for details). Exception is face validity, which is evaluated by the judgement of experts as an appropriate measure rather than by specific studies. NV, not valid: similarly, a criterion was judged not valid if appropriate information was available from studies including exclusively patients with PAH-SSc (quality definition A1, see table 1 for details). PV, partially validated: a criterion was judged partially validated if data from studies lower than quality level A1 indicated that the criterion is validated.
6MWT, 6 min walk test; NA, not applicable; ND, no data; PAH, pulmonary arterial hypertension; PAH-SSc, pulmonary arterial hypertension secondary to systemic sclerosis.