Table 1

Relative expression of genes and signalling molecules in passive K/BxN arthritis and collagen-induced arthritis

Gene/proteinPassive K/BxN arthritisCollagen-induced arthritis
EarlyMidLateEarlyMidLate
P-p38++++++++++++
P-JNK++++++++ (54 kDa only)+++ (54 kDa only)0
P-ERK++++0000
IRF7000+++0
IKKε000++++
IRF3000000
IL6++++++00+++0
IL10+++00+++
MMP-3+++++++0+++++
TNF000+00
IP10+++0+++++
RANTES0000+++0
IFNβ000000
  • Relative expression of phosphorylated proteins (P-p38, P-JNK, P-ERK) and mRNA for signalling molecules and cytokines during arthritis models. For K/BxN: early, day 1; mid, day 4–8; late, day 12. For collagen-induced arthritis: early, day 10–20; mid, day 30; late, day 40–50. 0, no change or decrease; +, minor change (approximately twofold); ++, moderate change; +++, major change.