Table 2

Genotype association with radiographic severity of knee osteoarthritis (OA) in two populations

NYUHJD population (n=80*)Duke POP study (n=50)
Geners NumberGenotypes comparedKellgren–Lawrence score >2 (odds ratio (CI))Kellgren–Lawrence score >2 (odds ratio (CI))
IL1A(+4845)rs17561GG vs GT/TT1.26 (0.48 to 3.28); p=0.63
IL1B(−511)rs16944CC vs CT/TT0.89 (0.32 to 2.47); p=0.82
IL1B(−1464)rs1143623GG vs GC/CC1.96 (0.75 to 5.11); p=0.17
IL1B(−3737)rs4848306CC vs CT/TT1.25 (0.45 to 3.48); p=0.68
IL1B(+3954)rs1143634CC vs CT/TT1.36 (0.53 to 3.47); p=0.52
IL1B(+3877)rs1143633GG vs GA/AA1.12 (0.43 to 2.91); p=0.81
IL1RN(+2018)rs419598TT vs CT/CC0.49 (0.175 to 1.37); p=0.1740.031 (0.004 to 0.27); p=0.0016
IL1RNrs315952CC/CT vs TT0.46 (0.15 to 1.20); p=0.1130.32 (0.090 to 1.00); p=0.071
IL1RNrs9005GG vs GA/AA0.25 (0.091 to 0.680); p=0.00670.084 (0.02 to 0.343); p=0.0006
IL1RN haplotypers419598/rs315952/rs9005Haplotype C,T,A (1 or 2 copies) vs no copies0.29 (0.09 to 0.93); p=0.0370.031 (0.004 to 0.270); p=0.0016
TNFA(−308)rs1800629GG vs GA/AA1.37 (0.040 to 4.70); p=0.62
IL10(−1082)rs1800896CC vs CT/TT3.00 (0.87 to 10.34); p=0.081
IL10(−819)rs1800871CC vs CT/TT3.32 (1.08 to 10.28); p=0.037
IL10(−592)rs1800872CC vs CA/AA3.32 (1.08 to 10.28)§; p=0.037
ESR1_PvuIIrs2234693TT vs CT/CC0.57 (0.22 to 1.49); p=0.25
ESR1_Xbalrs9340799AA vs AG/GG0.48 (0.18 to 1.25); p=0.13
  • Results in bold indicate significant association with decreased risk for severe OA.

  • * Number of Caucasian patients with knee osteoarthritis who met inclusion criteria and had complete genotype data.

  • IL1RN single nucleotide polymorphisms (SNPs) of interest from the NYUHJD population were then tested in the Duke POP population, and common haplotypes in the IL1RN gene were tested in both populations. p Values <0.05 were considered statistically significant. All other SNPs tested in the NYUHJD population were subsequently evaluated in the POP patients, and none were significant (data not shown).

  • For each single SNP, p values <0.027 were considered statistically significant to account for multiple comparisons in the discovery population (NYUHJD) involving 15 SNPs.

  • § IL10(−819) and IL10(−592) alleles were completely concordant in this population.

  • NYUHJD, New York University Hospital for Joint Diseases; POP, Prediction of Osteoarthritis Progression study.