Independent predictive variables for rapid radiographic progression (RRP) in the final fitted multivariate logistic regression model with all variables categorised
| Predictor of RRP | OR (95% CI) (model including CRP) | OR (95% CI) (model including ESR) |
|---|---|---|
| RF/ACPA | ||
| Both negative | Reference | Reference |
| One positive | 2.47 (1.01 to 6.07) | 2.64 (1.10 to 6.33) |
| Both positive | 4.04 (1.92 to 8.48) | 3.99 (1.91 to 8.33) |
| Erosions | ||
| 0 | Reference | Reference |
| 1–4 | 1.35 (0.59 to 3.06) | 1.19 (0.54 to 2.60) |
| ≥4 | 3.82 (1.64 to 8.89) | 2.97 (1.33 to 6.63) |
| CRP (mg/l) | ||
| <10 | Reference | – |
| 10–35 | 1.54 (0.74 to 3.22) | – |
| ≥35 | 4.76 (2.32 to 9.73) | – |
| ESR (mm/h) | ||
| <21 | – | Reference |
| 21–50 | – | 0.80 (0.41 to 1.58) |
| ≥50 | – | 2.73 (1.40 to 5.33) |
| Treatment | ||
| Monotherapy | Reference | Reference |
| Combined with prednisone | 0.20 (0.10 to 0.40) | 0.30 (0.15 to 0.57) |
| Combined with infliximab | 0.14 (0.07 to 0.30) | 0.14 (0.07 to 0.31) |
CRP, C-reactive protein; ESR, erythrocyte sedimentation rate; RF/ACPAs, rheumatoid factor/anti-citrullinated protein antibodies.