Serum levels of molecular markers in the mitochondrial DNA (mtDNA) haplogroups H, U and J
| Haplogroup H (n=50) | Haplogroup U (n=50) | Haplogroup J (n=50) | |||||
|---|---|---|---|---|---|---|---|
| Markers | Mean (SD) | Median | Mean (SD) | Median | Mean (SD) | Median | p Value* |
| Coll2-1 (nM) | 151.78 (30.79) | 151.48 | 123.51 (41.72) | 121.75 | 122.59 (54.10) | 119.17 | <0.001† |
| Coll2-1NO2 (nM) | 0.41 (0.16) | 0.38 | 0.31 (0.17) | 0.31 | 0.31 (0.22) | 0.32 | 0.002† |
| Coll2-1NO2/Coll2-1 (nM) | 0.27 (0.08) | 0.25 | 0.24 (0.09) | 0.23 | 0.25 (0.19) | 0.23 | 0.042 |
| C2C (ng/ml) | 126.19 (40.70) | 127.32 | 81.53 (44.59) | 80.02 | 57.75 (38.33) | 54.95 | <0.001† |
| CPII (ng/ml) | 536.02 (241.07) | 541.36 | 365.81 (222.14) | 329.46 | 334.40 (203.36) | 275.21 | <0.001† |
| C2C/CPII (ng/ml) | 0.270 (0.12) | 0.26 | 0.25 (0.09) | 0.22 | 0.20 (0.26) | 0.16 | <0.001† |
| HA (ng/ml) | 61.76 (44.89) | 44.5 | 49.84 (32.65) | 41 | 63.02 (37.29) | 56 | 0.324 |
| YKL-40 (ng/ml) | 105.50 (81.98) | 76.36 | 111.88 (98.91) | 74.5 | 93.81 (80.39) | 76.45 | 0.703 |
↵* Kruskal–Wallis non-parametric test.
↵† Indicates statistical significance (p<0.01).
C2C, a C-terminal neoepitope generated by the collagenase-mediated cleavage of collagen type II triple helix; Coll2-1, collagen type II (and its nitrated form, Coll2-1NO2); CPII, procollagen type II C-terminal propeptide; HA, hyaluronic acid; YKL-40, cartilage glycoprotein 39.