Serum levels of molecular markers in healthy controls and patients with osteoarthritis (OA)
| Healthy controls (n=77) | OA (n=73) | ||||
|---|---|---|---|---|---|
| Markers | Mean (SD) | Median | Mean (SD) | Median | p Value* |
| Age, years | 66.01 (11.88) | 66.00 | 67.74 (8.96) | 69.00 | |
| Women/men | 39/38 | 52/21 | |||
| Coll2-1, nM | 140.77 (40.22) | 141.65 | 124.03 (48.48) | 123.06 | 0.029 |
| Coll2-1NO2, nM | 0.34 (0.13) | 0.35 | 0.36 (0.24) | 0.32 | 0.891 |
| Coll2-1NO2/Coll2-1, nM | 0.24 (0.09) | 0.23 | 0.27 (0.16) | 0.26 | 0.211 |
| C2C, ng/ml | 101.32 (46.53) | 96.63 | 74.95 (50.10) | 60.11 | 0.002† |
| CPII, ng/ml | 431.83 (223.08) | 440.36 | 391.24 (253.44) | 328.24 | 0.249 |
| C2C/CPII, ng/ml | 0.28 (0.23) | 0.24 | 0.20 (0.07) | 0.19 | <0.001† |
| HA, ng/ml | 47.27 (32.65) | 36 | 69.74 (41.58) | 58 | <0.001† |
| YKL-40, ng/ml | 112.68 (101.45) | 74.74 | 94.30 (68.66) | 76.97 | 0.648 |
↵* Mann–Whitney non-parametric U test.
↵† Indicates statistical significance (p<0.01).
C2C, a C-terminal neoepitope generated by the collagenase-mediated cleavage of collagen type II triple helix; Coll2-1, collagen type II (and its nitrated form, Coll2-1NO2); CPII, procollagen type II C-terminal propeptide; HA, hyaluronic acid; YKL-40, cartilage glycoprotein 39.