Table 3

Sensitivity to change after tumour necrosis factor (TNF) blocker therapy of the different clinical and ultrasonographic scoring systems in 68 patients with rheumatoid arthritis

Sensitivity to change
Scoring systemBaseline*After 1 month of therapy*End of the study (final)*Between final and baselineBetween final and month 1
Joint count
20 Clinical4.97±3.303.00±3.122.07±2.62−0.96±0.15−0.33±0.12
20 US B mode10.58±4.029.55±4.097.90±4.35−0.60±0.12−0.44±0.13
20 US power Doppler5.28±4.134.00±3.932.76±2.76−0.69±0.16−0.38±0.12
28 Clinical9.61±4.926.27±5.024.60±5.12−1.12±0.13−0.34±0.14
28 US B mode12.88±6.2010.81±5.989.12±6.19−0.64±0.13−0.38±0.13
28 US power Doppler7.00±5.395.20±4.574.16±3.93−0.62±0.13−0.37±0.12
38 Clinical10.53±5.356.60±5.214.93±5.28−1.13±0.15−0.33±0.14
38 US B mode18.18±7.0715.71±6.8613.25±7.22−0.64±0.14−0.43±0.12
38 US power Doppler9.15±6.306.63±5.245.16±4.55−0.70±0.15−0.40±0.13
Clinical DAS28 ESR5.16±1.294.05±1.373.47±1.37−1.36±0.16−0.60±0.14
US B mode DAS28 ESR5.24±1.284.27±1.353.78±1.34−1.19±0.18−0.57±0.13
US power Doppler DAS28 ESR4.95±1.303.95±1.373.48±1.35−1.21±0.15−0.55±0.11
Joint score
20 Clinical14.69±10.088.91±8.236.87±7.30−0.98±0.13−0.32±0.13
20 US B mode20.92±10.7317.53±8.8313.78±9.05−0.76±0.13−0.51±0.14
20 US power Doppler9.08±8.196.58±7.074.16±5.13−0.75±0.13−0.40±0.12
28 Clinical26.02±14.0317.81±13.7513.66±13.08−1.06±0.13−0.35±0.13
28 US B mode25.60±15.5119.56±13.4315.62±12.87−0.82±0.12−0.46±0.13
28 US power Doppler12.11±10.248.33±8.696.34±7.140.81±0.13−0.41±0.10
38 Clinical29.73±16.4519.45±14.5915.13±14.56−1.06±0.15−0.33±0.13
38 US B mode35.16±17.7427.87±14.3422.52±14.85−0.82±0.15−0.51±0.16
38 US power Doppler15.44±12.0110.26±8.847.66±8.14−0.88±0.14−0.46±0.14
  • * Values given are mean ± SD.

  • Sensitivity to change was evaluated using the standardised response mean (see Patients and methods section). The SD of the standardised response mean was estimated using bootstrap resampling methodology.

  • See Patients and methods section for the definition of count vs score and for the description of the evaluated joints.

  • DAS28, 28-joint Disease Activity Score; ESR, erythrocyte sedimentation rate; US, ultrasound.