Arthritis development is associated with IgM-RF in the presence of ACPA
| HR (95% CI) | HR (95% CI) | |
|---|---|---|
| ACPA negative* (reference group) | 1 (−) | − (−) |
| Model 1 | ||
| ACPA positive, IgM-RF negative | 3.2 (0.8 to 12.2) | 1 (−) |
| ACPA positive, IgM-RF positive | 9.8 (2.9 to 33.4) | 3.0 (1.4 to 6.9) |
| Model 2 | ||
| ACPA positive, SE negative | 6.1 (1.8 to 21.2) | 1 (−) |
| ACPA positive, SE positive | 6.0 (1.7 to 21.5) | 1 (0.5 to 2.1) |
↵* Thus only IgM-RF positive.
ACPA, anti-citrullinated protein antibodies; 95% CI, 95% confidence interval; HR, hazard ratio; RF, rheumatoid factor; SE, shared epitope.