HLA-class II allelic frequencies significantly associated with anti-RNA polymerase III positive antibody positive Caucasian, African-American and Hispanic patients with systemic sclerosis (SSc) compared with ethnically matched normal controls using logistic regression.
| SSc (%) | Controls (%) | Model (D/R/A) | p Value | OR | 95% CI | |
|---|---|---|---|---|---|---|
| Caucasian† | ||||||
| DRB1 | ||||||
| *0404 | 7.5 | 1.9 | D | <0.0001 | 5.13 | 2.4 to 11.0 |
| *11 | 12.4 | 8.2 | A | 0.02 | 6.78 | 1.2 to 37.7 |
| 1.55 | 0.9 to 2.6 | |||||
| *1104 | 6.1 | 3.0 | D | 0.02 | 2.34 | 1.2 to 4.6 |
| DQB1 | ||||||
| *03 | 40.6 | 30.1 | R | 0.004 | 2.38 | 1.3 to 4.2 |
| *0301 | 22.9 | 16.8 | A | 0.01 | 3.77 | 1.3 to 11.0 |
| 1.50 | 1.002 to 2.26 | |||||
| African-American‡ | ||||||
| DRB1 | ||||||
| *08 | 13.6 | 5.5 | D | 0.003 | 3.92 | 1.7 to 9.2 |
| *0804 | 9.1 | 3.6 | D | 0.05 | 2.98 | 1.04 to 8.5 |
| 1104 | 3.0 | 1.9 | NS | |||
| DQA1 | ||||||
| *0501 | 42.2 | 24.1 | A | 0.003 | 6.03 | 1.5 to 23.8 |
| 3.10 | 1.3 to 7.2 | |||||
| DQB1 | ||||||
| *0301 | 37.5 | 21.9 | D | 0.002 | 3.60 | 1.6 to 8.0 |
| Hispanic§ | ||||||
| DRB1 | ||||||
| *11 | 12.5 | 5.6 | D | 0.10 | 2.17 | 2.0 to 11.6 |
| *1104 | 3.8 | 2.0 | D | 0.005 | 10.50 | 2.3 to 46.8 |
| DQA1 | ||||||
| *0501 | 28.8 | 21.7 | R | 0.047 | 3.65 | 1.1 to 12.6 |
| DQB1 | ||||||
| *03 | 50.0 | 34.1 | D | 0.04 | 2.33 | 1.1 to 5.1 |
| *0301 | 32.5 | 14.9 | D | 0.0002 | 4.07 | 2.0 to 8.5 |
| *DQB1 26 epi | 78.0 | 61.7 | – | 0.04 | 2.39 | 1.1 to 5.4 |