Table 4

HLA-class II allelic frequencies significantly associated with anticentromere antibody positive Caucasian and Hispanic patients with systemic sclerosis (SSc) compared with ethnically matched normal controls using logistic regression

SSc (%)Controls (%)Model (D/R/A)p ValueOR95% CI
Caucasian
DRB1
 *0121.012.5D<0.00012.191.5 to 3.2
 *010116.68.2D<0.00012.721.8 to 4.1
 *0424.911.7D0.00041.901.3 to 2.7
 *040111.08.3R0.038.981.4 to 57.2
 *04045.51.9D<0.00014.182.0 to 8.6
 *07012.914.2A<0.00010.100.01 to 0.8
0.140.1 to 0.2
 *086.13.4D0.041.901.1 to 3.4
 08014.82.0D0.033.171.5 to 6.6
 *1111.98.2D0.021.671.1 to 2.6
 *11045.03.0NS
 *15018.914.3R0.0060.670.4 to 1.02
0.160.03 to 0.7
DQA1
 *010123.113.4D<0.00012.571.8 to 3.7
 *010214.421.3R0.0010.250.1 to 0.6
 *02013.014.4A<0.00010.070.01 to 0.6
0.150.1 to 0.2
DQB1
 *02025.32.8D<0.00010.140.07 to 0.3
 *030123.516.8R0.0043.411.4 to 8.0
 *030214.69.4D0.0072.041.2 to 3.4
 *050122.812.6D<0.00012.562.0 to 3.7
 *DQB1 26 epi75.153.8<0.00012.932.0 to 4.2
DPB1
 *13011.51.4NS
Hispanic
DRB1
 *040726.06.8D0.00095.072.0 to 12.9
  • SSc cases (n = 281) versus normal controls (n = 539) in Caucasian subjects;

  • SSc cases (n = 25) versus normal controls (n = 198) in Hispanic subjects; NS=not significant for any of the three models