Mean difference in change in Health Assessment Questionnaire (HAQ) over 10 years by time to, and time receiving, treatment—adjusted by baseline HAQ and marginal structural weight
| Difference in change in HAQ between baseline and year 10, compared with never treated | |||||
|---|---|---|---|---|---|
| Adjusted by baseline HAQ | Adjusted by marginal structural weight | ||||
| n | Mean | (95% CI) | Mean | (95% CI) | |
| Treated over follow-up | 345 | 0.30 | (0.18 to 0.42) | −0.01 | (−0.20 to 0.19) |
| Time to first treatment | |||||
| <6 Months | 122 | 0.13 | −0.04 to 0.3) | −0.24 | (−0.58 to 0.09) |
| 6–12 Months | 76 | 0.35 | (0.15 to 0.54) | 0.12 | (−0.13 to 0.37) |
| >12 Months | 147 | 0.39 | (0.24 to 0.54) | 0.18 | (−0.06 to 0.41) |
| Effect of first treatment duration | |||||
| ≤6 Months | 91 | 0.41 | (0.23 to 0.59) | 0.28 | (0.04 to 0.52) |
| >6–≤36 Months | 123 | −0.10 | (−0.31 to 0.1) | −0.25 | (−0.56 to 0.06) |
| >36 Months | 131 | −0.10 | (−0.28 to 0.09) | −0.37 | (−0.77 to 0.04) |
| Effect of treatment duration over 10 years | |||||
| ≤48 Months | 88 | 0.08 | (−0.1 to 0.26) | −0.21 | (−0.62 to 0.21) |
| >48–≤96 Months | 57 | 0.35 | (0.1 to 0.6) | 0.53 | (−0.01 to 1.06) |
| >96 Months | 200 | −0.07 | (−0.29 to 0.15) | −0.37 | (−0.77 to 0.04) |
| Effect per number of months of first treatment | |||||
| No of months treated in first 6 months since symptom onset | — | −0.09 | (−0.15 to −0.03) | −0.09 | (−0.17 to −0.01) |
| No of months treated after first 6 months since symptom onset | — | −0.002 | (−0.004 to 0.0001) | −0.004 | (−0.01 to −0.0004) |
| Effect per number of months of treatment over 10 years | |||||
| No of months treated in first 6 months since symptom onset | — | −0.10 | (−0.16 to −0.04) | −0.10 | (−0.19 to −0.02) |
| No of months treated after first 6 months since symptom onset | — | 0.003 | (0.001 to 0.005) | 0.001 | (−0.002 to 0.005) |