Treated over follow-up | 345 | 0.30 | (0.18 to 0.42) | −0.01 | (−0.20 to 0.19) |
Time to first treatment |
<6 Months | 122 | 0.13 | −0.04 to 0.3) | −0.24 | (−0.58 to 0.09) |
6–12 Months | 76 | 0.35 | (0.15 to 0.54) | 0.12 | (−0.13 to 0.37) |
>12 Months | 147 | 0.39 | (0.24 to 0.54) | 0.18 | (−0.06 to 0.41) |
Effect of first treatment duration |
≤6 Months | 91 | 0.41 | (0.23 to 0.59) | 0.28 | (0.04 to 0.52) |
>6–≤36 Months | 123 | −0.10 | (−0.31 to 0.1) | −0.25 | (−0.56 to 0.06) |
>36 Months | 131 | −0.10 | (−0.28 to 0.09) | −0.37 | (−0.77 to 0.04) |
Effect of treatment duration over 10 years |
≤48 Months | 88 | 0.08 | (−0.1 to 0.26) | −0.21 | (−0.62 to 0.21) |
>48–≤96 Months | 57 | 0.35 | (0.1 to 0.6) | 0.53 | (−0.01 to 1.06) |
>96 Months | 200 | −0.07 | (−0.29 to 0.15) | −0.37 | (−0.77 to 0.04) |
Effect per number of months of first treatment |
No of months treated in first 6 months since symptom onset | — | −0.09 | (−0.15 to −0.03) | −0.09 | (−0.17 to −0.01) |
No of months treated after first 6 months since symptom onset | — | −0.002 | (−0.004 to 0.0001) | −0.004 | (−0.01 to −0.0004) |
Effect per number of months of treatment over 10 years |
No of months treated in first 6 months since symptom onset | — | −0.10 | (−0.16 to −0.04) | −0.10 | (−0.19 to −0.02) |
No of months treated after first 6 months since symptom onset | — | 0.003 | (0.001 to 0.005) | 0.001 | (−0.002 to 0.005) |