Relation between baseline biomarker values and percentage change in cartilage volume at 2 years
| β (estimate) | Medial 95% Cl | p Value | β (estimate) | Lateral 95% Cl | p Value | |
|---|---|---|---|---|---|---|
| Univariate biomarker analysis (n=142) | ||||||
| MMP-1 (ng/ml) | 0.0035 | (0.0001 to 0.0068) | 0.04 | −0.0004 | (−0.0029 to 0.0022) | 0.79 |
| MMP-3 (ng/ml) | −0.0004 | (−0.0018 to 0.0010) | 0.59 | −0.0003 | (−0.0014 to 0.0007) | 0.54 |
| IL-6 (pg/ml) | −0.0044 | (−0.0085 to −0.0003) | 0.04 | −0.002 | (−0.005 to 0.001) | 0.28 |
| CRP (mg/l) | −0.0012 | (−0.0020 to −0.0003) | 0.01 | −0.0003 | (−0.0010 to 0.0003) | 0.29 |
| COMP (ng/ml) | 1.3×10−6 | (−24.8×10−6 to 27.4×10−6) | 0.92 | −4.1×10−5 | (−5.9×10−5 to −2.2×10−5) | <0.01 |
| CTX-I (ng/ml) | 0.01 | (−0.04 to 0.06) | 0.65 | −0.03 | (−0.07 to 0.01) | 0.10 |
| U-CTX-II (ng/mmol creatinine) | −2.3×10−7 | (−4.8×10−5 to 4.7×10−5) | 0.99 | −1.4×10−5 | (−5.1×10−5 to 2.2×10−5) | 0.44 |
| Multivariate biomarker analysis (n=125)* | ||||||
| MMP-1 (ng/ml) | 0.0037 | (0.0003 to 0.0071) | 0.03 | −0.0002 | (−0.0028 to 0.0023) | 0.85 |
| MMP-3 (ng/ml) | −0.0008 | (−0.001 to 0.002) | 0.55 | −0.0006 | (−0.0018 to 0.0006) | 0.33 |
| IL-6 (pg/ml) | −0.005 | (−0.0088 to −0.0005) | 0.03 | −0.002 | (−0.005 to 0.001) | 0.31 |
| CRP (mg/l) | −0.0012 | (−0.0020 to −0.0004) | 0.01 | −0.0002 | (−0.0008 to 0.0005) | 0.59 |
| COMP (ng/ml) | 1.0×10−5 | (−17.3×10−6 to 38.1×10−6) | 0.46 | −3.8×10−5 | (−5.7×10−5 to −1.9×10−5) | <0.01 |
| CTX-I (ng/ml) | 0.02 | (−0.03 to 0.07) | 0.40 | −0.03 | (−0.07 to 0.01) | 0.11 |
| U-CTX-II (ng/mmol creatinine) | −1.2×10−5 | (−6.3×10−5 to 3.8×10−5) | 0.63 | −2.8×10−5 | (−6.5×10−5 to 8.9×10−5) | 0.14 |
| Multivariate biomarker analysis (n=125)† | ||||||
| MMP-1 (ng/ml) | 0.0037 | (0.0002 to 0.0072) | 0.04 | −0.0009 | (−0.0035 to 0.0016) | 0.46 |
| MMP-3 (ng/ml) | −8.3×10−5 | (−0.002 to 0.002) | 0.93 | 0.0004 | (−0.0010 to 0.0018) | 0.58 |
| IL-6 (pg/ml) | −0.003 | (−0.008 to 0.001) | 0.17 | −0.002 | (−0.005 to 0.002) | 0.33 |
| CRP (mg/l) | −0.0009 | (−0.0020 to 0.0002) | 0.10 | −0.0002 | (−0.0010 to 0.0006) | 0.69 |
| COMP (ng/ml) | 3.5×10−6 | (−28.4×10−6 to 35.3×10−6) | 0.83 | −3.7×10−5 | (−6.0×10−5 to −1.4×10−5) | <0.01 |
| CTX-I (ng/ml) | 0.04 | (−0.02 to 0.10) | 0.18 | −0.02 | (−0.06 to 0.02) | 0.32 |
| U-CTX-II (ng/mmol creatinine) | −2.9×10−5 | (−8.1×10−5 to 2.3×10−5) | 0.27 | −1.5×10−5 | (−5.3×10−5 to 2.3×10−5) | 0.43 |
↵* Adjusted for age, sex and treatment.
↵† Adjusted for age, sex, treatment and all biomarkers.
COMP, cartilage oligomeric matrix protein; CRP, C reactive protein; CTX-I, type I collagen C-terminal telopeptide; IL-6, interleukin-6; MMP, matrix metalloproteinase; U-CTX-II, urinary type II collagen C-terminal telopeptide.