Table 3

Baseline and 6-month changes in measures of disease activity*

BaselineΔ6 months crude dataΔ6 months adjusted analysis†
PsA (n=430)RA (n=1218)p ValuePsA (n=330)RA (n=929)p ValuePsA‡ (n=330)RA‡ (n=929)p Value
28-SJC4.8±4.5 4 (2–7)7.8±5.9 6 (3–11)<0.001§−2.3 (−2.8 to −1.8)−4.4 (−4.8 to −4.0)<0.001¶−4.0 (−4.4 to −3.6)−3.8 (−4.0 to −3.6)0.51
28-TJC6.3±5.5 5 (2–9)8.5±6.9 7 (3–13)<0.001§−2.1 (−2.7 to −1.5)−4.3 (−4.8 to −3.8)<0.001¶−3.2 (−3.8 to −2.6)−3.9 (−4.2 to −3.6)0.04
ESR (mm/h)22.2±19.0 16 (8–30)28.9±22.9 22 (12–41)<0.001§−3 (−14 to −1)−7 (−21 to −0)0.001§−9.8 (−11.6 to −8.1)−10.5 (−11.5 to −9.5)0.51
CRP (mg/l)16.5±17.3 10 (5–23)23.7±27.8 13 (5–31)<0.001§−2 (−11 to −0)−5 (−18 to −0)0.006§−10.3 (−12.2 to −8.3)−10.3 (−11.4 to −9.1)1.00
DAS284.42±1.17 4.40 (3.70–5.23)5.02±1.30 5.01 (4.13–5.92)<0.001¶−0.94 (−1.09 to −0.79)−1.45 (−1.56 to −1.34)<0.001¶−1.13 (−1.28 to −0.97)−1.38 (−1.47 to −1.29)0.006
Physician global VAS (0–100 mm)34.8±15.5 33 (24–44)41.1±17.4 40 (29–52)<0.001¶−14.9 (−17.1 to −12.8)−20.6 (−21.9 to −19.2)<0.001¶−18.8 (−20.6 to −17.1)−19.2 (−20.2 to −18.2)0.74
  • * Values are mean±SD and median (interquartile range) for baseline values, and mean (95% CI) or median (interquartile range) for changes.

  • ANCOVA with adjustment for age, sex and the respective baseline values testing PsA vs RA.

  • Estimated marginal means.

  • § Mann–Whitney U test.

  • Two-sample t test.

  • 28-SJC and 28-TJC, 28-joint swollen and tender joint counts, respectively; CRP; C-reactive protein; DAS28, disease activity score-28; ESR, erythrocyte sedimentation rate; PsA, psoriatic arthritis; RA, rheumatoid arthritis; VAS, visual analogue scale.