Odds ratios for developing rheumatoid arthritis (RA) according to presence or absence of SE, PTPN22 R620W and PADI4_94 risk alleles: allele 2 (minor allele) vs allele 1 (common allele)
| Presence of risk allele | All cases | CCP positive cases | CCP negative cases | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PADI4_94 | PTPN22 | Case:control | OR (95% CI) | AP (CI) | Case:control | OR (95% CI) | AP (CI) | Case:control | OR (95% CI) | AP (CI) |
| None | None | 876:810 | Referent | 0.0 (–0.4 to 0.4) | 340:810 | Referent | 0.0 (–0.3 to 0.3) | 182:810 | Referent | 0.0 (–0.4 to 0.4) |
| Present | None | 1771:1618 | 1.0 (0.9 to 1.1) | 680:1618 | 1.0 (0.9 to 1.2) | 349:1618 | 1.0 (0.8 to 1.2) | |||
| None | Present | 334:191 | 1.6 (1.3 to 2.0) | 146:191 | 1.8 (1.4 to 2.3) | 51:191 | 1.2 (0.8 to 1.7) | |||
| Present | Present | 679:386 | 1.6 (1.4 to 1.9) | 300:386 | 1.9 (1.5 to 2.3) | 102:386 | 1.2 (0.9 to 1.5) | |||
| PADI4_94 | SE | |||||||||
| None | None | 244:231 | Referent | 0.1 (–0.1 to 0.3) | 62:231 | Referent | 0.1 (–0.1 to 0.3) | 94:231 | Referent | 0.2 (–0.1 to 0.5) |
| Present | None | 503:478 | 1.0 (0.8 to 1.2) | 154:478 | 1.2 (0.9 to 1.7) | 162:478 | 0.8 (0.6 to 1.1) | |||
| None | Present | 747:214 | 3.3 (2.6 to 4.2) | 382:214 | 6.7 (4.8 to 9.2) | 118:214 | 1.4 (1.0 to 1.9) | |||
| Present | Present | 1500:378 | 3.8 (3.0 to 4.6) | 747:378 | 7.4 (5.4 to 10.0) | 240:378 | 1.6 (1.2 to 2.1) | |||
| PTPN22 | SE | |||||||||
| None | None | 553:563 | Referent | 0.3 (0.1 to 0.5) | 145:563 | Referent | 0.4 (0.1 to 0.6) | 204:563 | Referent | 0.2 (–0.1 to 0.5) |
| Present | None | 200:141 | 1.4 (1.1 to 1.8) | 71:141 | 2.0 (0.7 to 5.7) | 52:141 | 1.0 (0.7 to 1.5) | |||
| None | Present | 1610:474 | 3.5 (3.0 to 4.0) | 779:474 | 6.4 (5.1 to 7.9) | 270:474 | 1.6 (1.3 to 2.0) | |||
| Present | Present | 626:116 | 5.5 (4.4 to 6.9) | 347:116 | 11.6 (8.8 to 15.3) | 87:116 | 2.1 (1.5 to 2.9) | |||
Present, 1 or 2 copies of SE, PTPN22 R620W risk allele or PADI4_94 putative risk allele. Significant results in bold.
None, no copies.
AP, attributable proportion; CCP, cyclic citrullinated peptide; SE, shared epitope.