Table 3

Details of studies included in meta-analysis and subsequent analysis of SE, PTN22 and PADI4_94 risk allele combinations

Sample sizePADI4_94 allele 2 vs 1
StudyPopulationRA casesControlsOR (95% CI)p Value
Martinez (2005)9Spain2483941.01 (0.80 to 1.26)1.00
Harney (2005)8UK100941.20 (0.80 to 1.80)0.41
Plenge (2005): EIRA10Sweden14988581.01 (0.89 to 1.14)0.93
Plenge (2005): NARAC10North America8957481.24 (1.06 to 1.42)0.003
Hoppe (2006)13German1021021.55 (1.05 to 2.30)0.04
Costenbader (2008)19North America4304261.07 (0.89 to 1.30)0.49
WTCCCUK1859105990.98 (0.91 to 1.05)0.58
Current cohortUK373230391.02 (0.95 to 1.09)0.72
  • EIRA, Epidemiological Investigation of Rheumatoid Arthritis; NARAC, North American Rheumatoid Arthritis Consortium; SE, shared epitope; WTCCC, Wellcome Trust Case Control Consortium.