Table 2

PADI4_94 genotype in current cohort stratified by autoantibody status, carriage of SE, presence of erosions and gender

Cases*Controls*
111222Total111222TotalAllele 2 vs 1 OR (95% CI)p Trend
CCP +ve vs all controls498 (33.2)722 (48.2)279 (18.6)14991018 (33.5)1508 (49.6)513 (16.9)30391.04 (0.95 to 1.14)0.36
CCP −ve vs all controls241 (34.4)347 (49.5)113 (16.1)7011018 (33.5)1508 (49.6)513 (16.9)30390.97 (0.86 to 1.09)0.57
CCP +ve vs CCP −ve498 (33.2)722 (48.2)279 (18.6)1499241 (34.4)347 (49.5)113 (16.1)7011.08 (0.95 to 1.23)0.25
RF +ve vs all controls849 (33.4)1250 (49.1)444 (17.5)25431018 (33.5)1508 (49.6)513 (16.9)30391.01 (0.94 to 1.09)0.71
RF −ve vs all controls328 (34.2)467 (48.7)165 (17.2)9601018 (33.5)1508 (49.6)513 (16.9)30390.99 (0.89 to 1.10)0.89
Erosions394 (33.8)576 (49.4)195 (16.8)11651018 (33.5)1508 (49.6)513 (16.9)30390.99 (0.9 to 1.09)0.85
No erosions183 (33.0)270 (48.8)101 (18.2)5541018 (33.5)1508 (49.6)513 (16.9)30391.04 (0.91 to 1.18)0.57
SE +ve (1 or 2 copies)747 (33.3)1093 (48.6)407 (18.1)2247214 (36.2)276 (46.6)102 (17.2)5921.08 (0.95 to 1.23)0.24
SE −ve (0 copies)244 (32.7)373 (49.9)130 (17.4)747231 (32.6)359 (50.6)119 (16.8)7091.01 (0.87 to 1.17)0.88
Men334 (32.3)524 (50.7)176 (17.0)1034304 (32.6)471 (50.5)158 (16.9)9331.01 (0.89 to 1.15)0.91
Women896 (33.6)1294 (48.6)474 (17.8)2664657 (33.9)964 (49.8)315 (16.3)19361.04 (0.95 to 1.13)0.38
  • * Data shown as number (%).

  • 1, major (common) allele; 2, minor (rare) allele; RF, rheumatoid factor; SE, shared epitope.