Table 3

Influence of post-onset pregnancy status and cumulative autoantibody status on change in HAQ score over time, adjusted for age at symptom onset, symptom duration at baseline and number of previous live births

RF statusACPA status
NegativePositiveNegativePositive
Post-onset pregnancy
 NoRef.0.10Ref.0.17
 Yes−0.230.05−0.280.54
Difference in change in HAQ score by post-onset pregnancy status (95% CI)−0.23 (−0.34 to −0.12)*−0.05 (−0.22 to 0.11)−0.28 (−0.39 to −0.18)*0.37 (0.14 to 0.59)*
Results from stratified LRE models
Difference in change in HAQ score by post-onset pregnancy status (95% CI)−0.16 (−0.28 to −0.05)*−0.08 (−0.26 to 0.10)−0.23 (−0.34 to −0.12)*0.31 (0.05 to 0.56)*
  • In the top half of the table, autoantibody-negative women without a post-onset pregnancy are the reference group (Ref). Values represent difference in HAQ score from the reference group.

  • * Significant difference between HAQ scores of women who had a pregnancy and women who had not.

  • ACPA, anti-cyclic citrullinated peptide antibody; HAQ, Health Assessment Questionnaire; LRE, linear random effect; RF, rheumatoid factor.