Association between HLA-SE and rheumatoid arthritis (RA) risk in the Nurses’ Health Studies with stratification by serological status
| Model | HLA-SE | All RA, unadjusted* OR (95% CI) | All RA, adjusted† OR (95% CI) | Seropositive RA, adjusted‡ OR (95% CI) | Seronegative RA, adjusted‡ OR (95% CI) |
| General | None | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) |
| Single SE | 1.54 (1.13 to 2.10) | 1.60 (1.16 to 2.22) | 1.88 (1.34 to 2.65) | 1.07 (0.72 to 1.59) | |
| Double SE | 3.19 (1.88 to 5.43) | 3.78 (2.13 to 6.71) | 4.41 (2.53 to 7.68) | 1.55 (0.75 to 3.21) | |
| Dominant | None | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) | 1.0 (reference) |
| Any SE | 1.80 (1.35 to 2.41) | 1.90 (1.40 to 2.58) | 2.25 (1.64 to 3.10) | 1.14 (0.78 to 1.65) |
*Conditional logistic regression. †conditional logistic regression, adjusting for smoking (pack-years), parity, breast feeding and menstrual irregularity, and age at menarche, menopausal status and postmenopausal hormone use at diagnosis. ‡Unconditional logistic regression adjusting for year of birth, smoking (pack-years), parity, breast feeding and menstrual irregularity, and age at menarche, menopausal status and postmenopausal hormone use at blood draw and at diagnosis.
HLA-SE, human leukocyte antigen shared epitope; OR, odds ratio.