Independent risk factors for reduced survival in SSc patients by Cox regression modelling
| HR, 95% CI | |||||
|---|---|---|---|---|---|
| Risk factor | p Value | HR | Lower | Upper | χ2 |
| Presence of proteinuria (‘+’ or more on urine dipstick) | <0.001 | 3.343 | 2.114 | 5.286 | 49.6 |
| PAH | <0.001 | 2.018 | 1.440 | 2.827 | 63.1 |
| Pulmonary restriction (FVC <80% of normal) | 0.014 | 1.644 | 1.108 | 2.438 | 10.3 |
| Presence of dyspnoea (NYHA functional class III or IV) | 0.012 | 1.608 | 1.111 | 2.328 | 4.8 |
| Age at onset of Raynaud's phenomenon (per 10 years) | <0.001 | 1.295 | 1.158 | 1.448 | 21.8 |
| DLCO (per 10% decrease of normal) | <0.001 | 1.203 | 1.118 | 1.295 | 33.9 |
| mRSS (per 10 score points) | 0.024 | 1.198 | 1.025 | 1.402 | 4.3 |
Risk factors are ranked by HR. χ2 Scores indicate to what extent each factor helps improve prediction of mortality.
DLCO, diffusing capacity of the lung for carbon monoxide; FVC, forced vital capacity; mRSS, modified Rodnan skin score; NYHA, New York Heart Association; PAH, pulmonary arterial hypertension diagnosed by echocardiography.