Characteristics included and results of the univariate analysis
| HR (95% CI) | p Value | |
|---|---|---|
| Sex | 1.10 (0.71 to 1.72) | 0.6582 |
| Age | 1.24 (0.81 to 1.89) | 0.3144 |
| BMI | 1.15 (0.76 to 1.73) | 0.5121 |
| Disease duration | 1.70 (1.13 to 2.55) | 0.0109 |
| K&L radiological grade | 4.67 (2.73 to 8.01) | <0.0001 |
| Knee pain intensity on VAS | 1.82 (1.17 to 2.82) | 0.0074 |
| Joint effusion at clinical examination | 1.15 (0.75 to 1.76) | 0.5153 |
| Sudden aggravation of knee pain | 0.74 (0.49 to 1.13) | 0.1617 |
| Duration of morning stiffness | 1.41 (0.86 to 2.32) | 0.1686 |
| Night awakening due to knee pain | 1.07 (0.69 to 1.65) | 0.7730 |
| WOMAC pain subscale | 1.45 (0.94 to 2.22) | 0.0894 |
| WOMAC stiffness subscale | 1.36 (0.88 to 2.08) | 0.1614 |
| WOMAC function subscale | 1.27 (0.81 to 2.00) | 0.3053 |
| Patient's global assessment of clinical knee OA severity on VAS | 1.46 (0.95 to 2.25) | 0.0832 |
| Physician's global assessment of clinical knee OA severity on VAS | 1.88 (1.24 to 2.84) | 0.0031 |
| Ultrasonographic knee effusion depth | 3.06 (2.00 to 4.69) | <0.0001 |
| Ultrasonographic knee synovitis | 1.54 (0.95 to 2.50) | 0.0826 |
BMI, body mass index; HR, hazard ratio; K&L, Kellgren and Lawrence; OA, osteoarthritis; VAS, visual analogue scale; WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index.