The incidence rate (95% CI) of cardiovascular events by various combinations of traditional cardiovascular risk factors and markers of rheumatoid arthritis severity
| RA factors CV risk factors | 0 | 1 | 2 | 3+ |
|---|---|---|---|---|
| 0 | N=305 | N=820 | N=928 | N=1410 |
| Events=0 | Events=5 | Events=1 | Events=9 | |
| Person-years=502 | Person-years=1512 | Person-years=1805 | Person-years=2946 | |
| Rate 0 (0–5.98) | Rate 3.31 (0.41–6.20) | Rate 0.55 (0–1.64) | Rate 3.06 (1.06–5.05) | |
| 1 | N=287 | N=803 | N=923 | N=1613 |
| Events=2 | Events=7 | Events=5 | Events=12 | |
| Person-years=469 | Person-years=1422 | Person-years=1684 | Person-years=3315 | |
| Rate 4.27 (0–10.17) | Rate 4.92 (0.85–7.59) | Rate 2.97 (0.37–5.57) | Rate 3.62 (1.58–5.67) | |
| 2+ | N=200 | N=632 | N=754 | N=1481 |
| Events=1 | Events=4 | Events=10 | Events=20 | |
| Person-years=264 | Person-years=1013 | Person-years=1222 | Person-years=2678 | |
| Rate 3.80 (0–11.22) | Rate 3.95 (0.09–7.81) | Rate 8.18 (3.13–13.24) | Rate 7.47 (4.21–10.73) |
Incidence rate per 1000 person-years (95% CI). Traditional CV risk factors include diabetes, hypertension, hyperlipidemia, tobacco use, known CV disease, a family history of premature CV disease, age ≥75 years and male gender. Markers of RA severity include disease duration >5 years, the presence of radiographic joint erosions, the presence of subcutaneous nodules, a prior total joint replacement, modified HAQ score ≥2, a Clinical Disease Activity Index score >22 and seropositivity.