Table 3

Risk factors of lymphoma for patients receiving anti-TNF agents (multivariate analysis: main analysis and analysis restricted to RA patients)

OR (95% CI)p Value
All lymphoma (37 cases and 74 controls)
Last anti-TNF agent received
    Etanercept1
    Adalimumab4.73 (1.27 to 17.65)0.02
    Infliximab4.12 (1.36 to 12.49)0.01
Time from onset of first anti-TNF treatment*
    <2 years3.30 (1.17 to 9.30)0.02
    ⩾2 years1 (Ref)
Lymphoma in RA patients (27 cases and 54 controls)
Last anti-TNF agent received
    Etanercept10.003
    Adalimumab or infliximab6.68 (1.90 to 23.54)
  • *Time from onset of the last anti-TNF treatment and first symptoms of lymphoma for cases, time from onset of the last anti-TNF treatment and last news for controls. OR, odds ratio; RA, rheumatoid arthritis.