Mean±SD values and mean differences (95% CI) in measures of pain, functioning and HRQL for patients with EOA (n=42) and patients with non-EOA (n=194)
| EOA | Non-EOA | p Value (t test) | Mean difference (95% CI)* | Mean difference taking nodes into account (95% CI)† | |
|---|---|---|---|---|---|
| Pain | |||||
| AUSCAN pain (0–20) | 9.0±4.8 | 7.0±4.8 | 0.016 | 2.0 (0.4 to 3.7) | 1.0 (−0.7 to 2.7) |
| MHQ pain (0–100) | 47.1±18.1 | 37.9±22.8 | 0.016 | 9.5 (2.0 to 17.0) | 3.9 (−3.9 to 11.7) |
| Number of painful joints (0–30) | 11.3±6.8 | 7.9±7.8 | 0.009 | 3.4 (0.9 to 6.0) | 1.5 (−1.2 to 4.2) |
| Pain intensity (0–90) | 8.7±7.2 | 6.6±7.0 | 0.082 | 2.1 (−0.2 to 4.4) | 1.0 (−1.5 to 3.5) |
| Functioning | |||||
| AUSCAN function (0–36) | 17.3±8.7 | 13.2±8.7 | 0.006 | 4.1 (1.2 to 6.9) | 3.0 (−0.1 to 6.1) |
| MHQ overall function (0–100) | 53.5±14.8 | 61.2±15.6 | 0.004 | −7.5 (−12.7 to −2.4) | −4.8 (−10.2 to 0.6) |
| MHQ ADL (0–100) | 73.2±19.4 | 79.3±17.8 | 0.049 | −6.3 (−12.2 to −0.3) | −4.4 (−10.8 to 1.9) |
| work performance (0–100) | 65.2±24.5 | 71.1±25.9 | 0.182 | −6.2 (−14.9 to 2.5) | −5.5 (−14.9 to 3.9) |
| Grip strength (kg) | 19.7±8.4 | 21.7±10.7 | 0.241 | −1.6 (−4.2 to 1.0) | −1.0 (−3.8 to 1.8) |
| Pinch grip (kg) | 3.2±1.8 | 3.2±1.5 | 0.872 | 0.1 (−0.3 to 0.6) | 0.1 (−0.4 to 0.6) |
| HAMIS (0–27) | 5.7±4.0 | 3.7±2.6 | <0.001 | 2.1 (1.2 to 3.0) | 1.2 (0.3 to 2.1) |
| Fingertip to palm distance (mm) | 54.0±52.1 | 15.1±27.3 | <0.001 | 39.1 (28.0 to 50.2) | 26.6 (15.4 to 37.8) |
| HRQL | |||||
| SF-36 PCS | 44.1±9.0 | 44.9±9.1 | 0.559 | −1.2 (−4.2 to 1.8) | −1.2 (−4.5 to 2.1) |
| SF-36 MCS | 50.2±9.4 | 50.6±10.5 | 0.800 | −0.1 (−3.5 to 3.4) | −0.4 (−4.1 to 3.3) |
| MHQ function satisfaction (0–100) | 45.5±19.6 | 61.6±25.6 | <0.001 | −16.1 (−24.4 to −7.7) | −11.0 (−19.8 to −2.1) |
| MHQ aesthetic satisfaction (0–100) | 74.6±15.2 | 85.4±16.3 | <0.001 | −10.9 (−16.3 to −5.5) | −8.6 (−14.3 to −2.8) |
| Number of IP joint nodes (0–18) | 15.0±3.0 | 10.6±4.6 | <0.001 | 4.4 (3.0 to 5.8) | NA |
↵* Adjusted for age, sex, BMI and family effects. Non-EOA was reference group.
↵† Adjusted for number of nodes, age, sex, BMI and family effects. Non-EOA was reference group.
ADL, activities of daily living; AUSCAN, Australian/Canadian Osteoarthritis Hand Index; BMI, body mass index; EOA, erosive osteoarthritis; HAMIS, Hand Mobility in Scleroderma; HRQL, health-related quality of life; IP, interphalangeal; MCS, Mental Component Summary Scale; MHQ, Michigan Hand Outcome Questionnaire; NA, not applicable; PCS, Physical Component Summary Scale; SF-36, Short Form-36.