Table 2

Mean changes in serum anti-cyclic citrullinated peptide (CCP) and rheumatoid factor (RF) levels

AbataceptPlacebo
Serum anti-CCP (U/ml)
Baseline (month 6 analysis)*227.6 (289.8)145.5 (98.2)
Month 6*133.1 (198.2)161.9 (155.3)
Mean change from baseline to month 6 (95% CI)*−94.5 (−156 to −33.0)16.3 (−28.8 to 61.5)
Baseline (year 1 analysis)270.0 (325.4)212.9 (131.3)
Year 1263.5 (430.0)362.4 (314.2)
Mean change from baseline to year 1 (95% CI)−6.5 (−110 to 97.4)149.5 (3.8 to 295.1)
Serum RF (U/ml)
Baseline (month 6 analysis)167.5 (249.8)63.5 (92.0)
Month 642.4 (46.3)61.5 (82.9)
Mean change from baseline to month 6 (95% CI)−125 (−218 to −32.1)−2.0 (−15.4 to 11.5)
Baseline (year 1 analysis)§137.0 (212.1)54.9 (51.5)
Year 1§96.3 (109.7)47.1 (53.9)
Mean change from baseline to year 1 (95% CI)§−40.7 (−133.0 to 51.3)−7.8 (235.2 to 19.6)
  • * n=21 and 19;

  • n=14 and 10;

  • n=22 and 20;

  • § n=15 and 10, for abatacept and placebo, respectively.