Table 1

Haplotype analysis of COMT and CWP

Frequency%
HaplotypePain sensitivityCasesControlsp Value*
EPIFUNDOMNIBUS0.587
GCGGLPS0.360.400.412
ATCAAPS0.550.510.317
ACCGHPS0.090.090.937
EMASOMNIBUS0.450
GCGGLPS0.380.420.461
ATCAAPS0.490.490.848
ACCGHPS0.120.090.169
  • * Wald test.

  • Adjusted for centre.

  • APS, average pain sensitivity; COMT, catechol-O-methyltransferase; CWP, chronic widespread pain; EMAS, European Male Ageing Study; EPIFUND, Epidemiology of Functional Disorders study; HPS, high pain sensitivity; LPS, low pain sensitivity.