Table 3

Rate of specific types of infection by treatment group

MTX(n = 4206)TNF antagonists(n = 1804)MTX + TNF antagonists(n = 2855)Other DMARDs(n = 1274)
Site of infection
    URI660 (12.8)303 (14.2)522 (13.0)148 (9.0)
    Sinusitis370 (7.2)166 (7.8)331 (8.2)71 (4.3)
    Urinary tract157 (3.1)81 (3.8)111 (2.8)32 (2.0)
    Cellulitis59 (1.3)49 (2.3)71 (1.8)18 (1.1)
    Non-pyogenic pneumonia51 (1.0)40 (1.9)61 (1.5)16 (1.0)
    Pyogenic pneumonia49 (1.0)22 (1.0)46 (1.1)22 (1.3)
    Bursitis9 (0.2)5 (0.2)7 (0.2)3 (0.2)
    Infectious arthritis9 (0.2)5 (0.2)5 (0.1)2 (0.2)
    Septicaemia8 (0.2)8 (0.4)10 (0.3)4 (0.2)
    Other342 (7.0)211 (9.9)350 (8.7)131 (7.9)
Type of infectious organism
    Opportunistic84 (1.6)63 (3.0)101 (2.5)28 (1.7)
    Non-opportunistic1436 (27.9)734 (34.5)1245 (30.9)378 (22.7)
All types of infection1714 (33.3)890 (41.8)1514 (37.6)447 (26.9)
  • Frequencies listed with crude rates per 100 person-years in parentheses. Totals differ as there were individual visits and intervals in which multiple infections were reported.

  • DMARD, disease-modifying antirheumatic drug; MTX, methotrexate; TNF, tumour necrosis factor; URI, upper respiratory infection.