Table 3

Serious infections in patients with AS

All studiesStudies included in the meta-analysis of the risk difference
Placebo + NSAIDs (2202 patients)TNF blockers (1243 patients)Placebo (500 patients)TNF blockers (996 patients)
% Serious infections*0.09 (0.01 to 0.3)1.1 (0.6 to 1.9)0.4 (0.0 to 1.4)0.7 (0.3 to 1.4)
Infections per 100 patient-years0.4 (0.0 to 4.5)2.2 (1.2 to 3.6)1.0 (0.1 to 11.6)1.9 (0.8 to 6.3)
  • * Results are reported as percentage of patients with at least one infection with range in parentheses.

  • AS, ankylosing spondylitis; NSAIDS, non-steroidal anti-inflammatory drugs; TNF, tumour necrosis factor.