Baseline characteristics of patients with induction-refractory disease compared with induction-responders in the WEGENT trial
| Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|
| Characteristics at diagnosis | Induction-refractory patients (n = 32) | Induction-responders (n = 126) | p Value | Adjusted OR* (95% CI) | p Value |
| Age (years) | 56.8 ± 16.1 | 58.0 ± 13.0 | 0.65 | – | |
| Sex (male) | 15 (46.9) | 61 (48.4) | 0.87 | – | |
| Ethnicity (white) | 32 (100) | 124 (98.4) | – | ||
| WG/MPA diagnosis | 24/8 | 96/30 | 0.89 | – | |
| Clinical manifestations | |||||
| Constitutional symptoms | 31 (96.9) | 112 (88.8) | 0.31 | – | |
| Ear, nose and throat | 23 (71.9) | 94 (74.6) | 0.65 | – | |
| Ophthalmological | 6 (18.8) | 33 (26.2) | 0.36 | – | |
| Cutaneous | 12 (37.5) | 35 (27.8) | 0.31 | – | |
| Pulmonary involvement | 28 (87.5) | 93 (73.8) | 0.13 | – | |
| Lung nodule | 16 (50.0) | 55 (43.7) | 0.47 | – | |
| Alveolar haemorrhage | 13 (40.6) | 26 (20.6) | 0.02 | 2.5 (1.1 to 5.8) | 0.03 |
| Cardiac failure | 3 (9.4) | 3 (2.4) | 0.10 | – | |
| Gastrointestinal tract | 4 (12.5) | 17 (13.5) | 1.0 | – | |
| Renal involvement | 26 (81.3) | 95 (75.4) | 0.58 | – | |
| Recent onset hypertension | 7 (21.9) | 7 (5.6) | 0.004 | – | NS |
| PNS | 5 (15.6) | 31 (24.6) | 0.40 | – | |
| CNS | 2 (6.3) | 9 (7.1) | 1.0 | – | |
| Biological findings | |||||
| Creatinine level (µmol/l) | 267.8 ± 255.6 | 175.9 ± 189.7 | 0.07 | – | |
| Creatinine level >200 µmol/l | 13 (40.6) | 25 (19.8) | 0.01 | 2.6 (1.2 to 6.1) | 0.03 |
| CRP level (mg/l) | 133.0 ± 104.0 | 97.8 ± 74.6 | 0.11 | – | |
| BVAS | 29.9 ± 9.1 | 22.4 ± 7.4 | 0.32 | – | |
| ANCA positivity (IIF) | 30 (93.8) | 113 (89.7) | 0.29 | – | |
Results are expressed as means ± SD or n (%).
↵* OR estimations were adjusted for the presence of alveolar haemorrhage and elevated creatinine level >200 µmol/l.
ANCA, antineutrophil cytoplasm autoantibody; BVAS, Birmingham Vasculitis Activity Score; CNS, central nervous system; CRP, C reactive protein; IIF, indirect immunofluorescence; MPA, microscopic polyangiitis; PNS, peripheral nervous system; WG, Wegener's granulomatosis.