Table 3

Regression analyses to predict change in bone marrow lesions at 2 years (n=143)

Medial compartmentMedial plateau
Independent variablesβp Valueβp Value
Univariate model
  Treatment: licofelone (1), naproxen (0)−0.2240.329−0.2200.062
Multivariate model without the percentage change in cartilage volume
 Treatment: licofelone (1), naproxen (0)−0.2290.340−0.2850.018
 Age (years)0.0180.2160.0120.120
 Gender: male (1), female (0)0.0710.778−0.0420.742
 BMI (kg/m2)0.0220.3100.0160.143
 Change in WOMAC (by unit of change)−0.0050.355−0.0020.417
 Severe medial extrusion at baseline: yes (1), no (0)0.0300.9330.2350.057
Multivariate model with the percentage change in cartilage volume
 Treatment: licofelone (1), naproxen (0)−0.1980.418−0.2800.026
 Age (years)0.0170.2530.0110.130
 Gender: male (1), female (0)0.0470.855−0.0460.724
 BMI (kg/m2)0.0180.4050.0160.155
 Change in WOMAC (by unit of change)−0.0050.291−0.0020.408
 Severe medial extrusion at baseline: yes (1), no (0)−0.0170.9630.2240.112
 % Change in cartilage volume−1.6330.478−0.2240.862
  • A negative parameter sign means that BML score progression was associated with less variable progression.

  • BMI, body mass index; BML, bone marrow lesion; WOMAC, Western Ontario and McMaster universities Osteoarthritis Index; β, parameter estimate.