Table 2

Baseline and change in bone marrow lesion score over time according to treatment

					Licofelone versus naproxen
	Total	p Value^*	Licofelone	Naproxen	p Value^†
Global
BL	3.68 (3.56)	–	4.20 (3.48)	3.14 (3.59)	0.060
Change from BL (months)
6	0.24 (1.14)	0.007	0.19 (1.01)	0.30 (1.25)	0.511
12	0.47 (1.40)	<0.001	0.34 (1.21)	0.61 (1.57)	0.227
24	0.71 (1.85)	<0.001	0.70 (1.82)	0.71 (1.88)	0.968
Medial (condyle + plateau)
BL	1.84 (2.38)	–	2.20 (2.50)	1.47 (2.21)	0.053
Change from BL (months)
6	0.09 (0.85)	0.166	0.00 (0.81)	0.19 (0.89)	0.160
12	0.21 (1.03)	0.010	0.06 (0.74)	0.37 (1.24)	0.061
24	0.33 (1.37)	0.005	0.21 (1.25)	0.44 (1.47)	0.329
Medial tibial plateau
BL	0.82 (1.13)	–	0.91 (1.20)	0.72 (1.05)	0.279
Change from BL (months)
6	0.03 (0.43)	0.355	−0.04 (0.40)	0.10 (0.44)	0.040
12	0.07 (0.49)	0.078	−0.01 (0.37)	0.15 (0.58)	0.036
24	0.10 (0.71)	0.099	−0.01 (0.65)	0.21 (0.74)	0.062

Results are shown as mean (±SD). Significant differences are shown in bold.
↵* Two-sided paired t tests;
↵† two-sided t tests comparing licofelone with naproxen.
BL, baseline.