Table 2

Baseline and change in bone marrow lesion score over time according to treatment

Licofelone versus naproxen
Totalp Value*LicofeloneNaproxenp Value
Global
 BL3.68 (3.56)4.20 (3.48)3.14 (3.59)0.060
 Change from BL (months)
  60.24 (1.14)0.0070.19 (1.01)0.30 (1.25)0.511
  120.47 (1.40)<0.0010.34 (1.21)0.61 (1.57)0.227
  240.71 (1.85)<0.0010.70 (1.82)0.71 (1.88)0.968
Medial (condyle + plateau)
 BL1.84 (2.38)2.20 (2.50)1.47 (2.21)0.053
 Change from BL (months)
  60.09 (0.85)0.1660.00 (0.81)0.19 (0.89)0.160
  120.21 (1.03)0.0100.06 (0.74)0.37 (1.24)0.061
  240.33 (1.37)0.0050.21 (1.25)0.44 (1.47)0.329
Medial tibial plateau
 BL0.82 (1.13)0.91 (1.20)0.72 (1.05)0.279
 Change from BL (months)
  60.03 (0.43)0.355−0.04 (0.40)0.10 (0.44)0.040
  120.07 (0.49)0.078−0.01 (0.37)0.15 (0.58)0.036
  240.10 (0.71)0.099−0.01 (0.65)0.21 (0.74)0.062
  • Results are shown as mean (±SD). Significant differences are shown in bold.

  • * Two-sided paired t tests;

  • two-sided t tests comparing licofelone with naproxen.

  • BL, baseline.