Table 1

Baseline demographic, clinical and imaging characteristics

CharacteristicsATP
Demographic and clinicalAll (n=161)Licofelone (n=82)Naproxen (n=79)
Age (years)60.2 (8.2)60.0 (8.7)60.4 (7.7)
Gender (F/M)107/5458/2449/30
Height (cm)165.2 (9.0)164.1 (8.6)166.3 (9.2)
Weight (kg)86.9 (17.6)87.6 (17.2)86.2 (18.1)
BMI (kg/m2)31.8 (5.8)32.5 (5.9)31.1 (5.5)
WOMAC
 Total56.9 (14.2)58.1 (13.6)55.7 (14.8)
 Pain57.8 (11.8)58.2 (11.9)57.4 (11.7)
 Function55.9 (6.5)57.1 (16.0)54.6 (17.1)
Imaging
 BML score
  Global3.68 (3.56)4.20 (3.48)3.14 (3.59)
  Medial compartment1.84 (2.38)2.20 (2.50)1.47 (2.21)
  Lateral compartment0.45 (1.13)0.39 (0.98)0.51 (1.28)
  Femoropatellar compartment1.39 (2.17)1.61 (2.47)1.16 (1.80)
 Cartilage volume (mm3)
  Global11904 (3154)11826 (3130)11986 (3196)
  Medial compartment4207 (1250)4224 (1258)4190 (1251)
  Lateral compartment4348 (1294)4283 (1264)4415 (1329)
  Femoropatellar compartment3348 (1121)3317 (1223)3380 (1010)
  • Results are shown as mean (SD).

  • ATP, according to protocol; BMI, body mass index; BML, bone marrow lesion (0=absence, 1 <25%, 2=25–50%, 3 >50% of the region's surface, global max. score 30); WOMAC, Western Ontario and McMaster Universities Osteoarthritis Index (0 = best, 100 = worst score).